Helminths are capable of improving neuropsychiatric function, and all four species of therapeutic helminth appear to make a positive contribution to psychological wellbeing.
Socio-medical studies of humans "self-treating" with
helminths as well as limited studies in animal models strongly suggest that
helminth therapy may be a productive approach toward treating a range of neuropsychiatric disorders, including chronic fatigue, migraine headaches, depression and anxiety disorders.
[1]Additional supporting research includes the following paper.
Reduced depression / improved mood[edit | edit source]
HDC is mentioned a lot in this context, and, since HDC is taken regularly, usually every 2 weeks, its users can benefit from a repeated post-inoculation 'bounce’. This is a brief period of temporary symptom relief accompanied by a sudden feeling of unusual wellness, perhaps with a strong sense of calm, focus, happiness and lightheartedness.
I like how it puts me in a good mood for a day or two when I first take it.
I also experienced a significantly elevated mood that night after taking just 10
HDC, the elevated mood lasted until the end of the next day.
[2]For some people, this effect may be repeated after every dose.
... every dose of
HDC's is followed by a delightful stream of energy that lasts almost a week.
[3]Within 24 hours of taking
HDC I feel much calmer. That feeling lasts a few days, before it lets up a bit, but I still continue feeling calmer than usual up to 30 days after dosing, when their effects completely wear off… If I could regularly dose, say, weekly, I probably would see my anxiety completely resolved.
[4]In other cases, this effect may reduce over time.
The first day I take
HDC it usually puts me in a really nice mood, especially the first time I did it. It's not exactly euphoric but I noticed it and counted on it… First time, (it lasted) 48 hours. Second time, 24 hours. Third time, 12 hours. Fourth time, 12 hours.
However, this effect on neuropsychiatric function is not unique to HDC. It is also seen with TSO, NA and TTO.
My mood was the first indicator that
TSO was working. I became calmer and happier despite my physical symptoms.
[5] I find
TSO is the best for mood and general feeling of well being as well as increased energy.
Hookworm and (human)
whipworm both work as well, it just takes longer.
[6]My daughter started
TSO last week and we are already seeing an improvement in her mood and energy on a low dose of 500 ova.
[7]TSO cured a mood disorder I didn't realize I had until it was gone.
[8] I would like to confirm positive
effect of
TSO on mood stabilization as well. Even with low dose in my case (300 ova bi-weekly).
[9]I didn't have depression, just a generally negative view of life, but
NA has (unexpectedly) made me a whole lot more positive and even happy.
[10] It's noticeable enough that I would continue with them even if that was the only benefit.
[11]The following comment was made 6 weeks after inoculation with 25 hookworm larvae.
What is already interesting is my steady and calm mind.
For further accounts of how helminthic therapy has reduced depression, see the following.
Temporarily increased depression[edit | edit source]
Occasionally, depression may increase temporarily following initial inoculation with helminths. This is usually, but not necessarily, the result of using doses that are too high.
After first small group of
NA, I became much more depressed for about 10-12 weeks, then got back to previous mood level.
[12]I have hit a patch of depression here at week 9 of my first
inoculation with 3NA and I am feeling very bleak.
[13]I also feel quite depressed, will be 9 weeks for me on Tuesday.
[14]After first small group of
NA, I became much more depressed for about 10-12 weeks, then got back to previous mood level.
[15]I experience plummeting mood following an
NA inoculation. Dosing amounts are important with
NA.
[16]When I used
HDC, I found that a high dose made me agitated, where a low dose would lift my depression within hours from the moment of taking it.
[17]My wife, who suffers from clinical depression, took 1
NA each month for 3 months. Then the Dr. told her to take 5 at once despite us asking multiple times if this would cause depression. We were told no each time. So my wife took the 5 at once as the doctor had suggested. A few days later, she began to get depressed and could not get out of bed for about 7-10 days. Cried all day. We killed the colony about 4 days later to prevent my wife from going to hospital because the depression was that bad. It was about another 2 weeks before she felt better again. (Edited from two posts:
[18] [19].)
3.5 years in, I now have times where I even feel positive and optimistic, which is a huge improvement over a lifetime of clinical depression. But it’s also the first symptom to return, especially if I take a dose of
NA that’s a little too much. Last dose was 7, and 3 days later I started 9 days of deep despair. I know it’s temporary, so I just hang on and get through it, but now I know 7 is too many.
[20]… the participant abruptly halted his antidepression medications and began taking
HDCs. Although confident in his actions because of the effects of
HDCs on his adult daughter and a friend, the outcome was severe depression. The participant resumed his medication and, fortunately, recovered rapidly.
[21]The potential for helminths to reduce anxiety can be seen in the reports in the following page section.
And in this paper. (See Table 1 in particular.)
Temporarily increased anxiety[edit | edit source]
There have been a few reports of anxiety increasing following initial inoculation with NA, TTO or HDC, but this increase is usually temporary and often related to dose size.
I think it aggravated the anxiety component for me. Not sure why. (After dosing with
HDC)
Around day 15 (after an initial dose of 10
NA), I had severe anxiety for 2 days straight but nothing since.
[22]I had mild/moderate diffuse anxiety for about a week at ~19-20 weeks. (After a supplementary dose of
65 NA!)
My anxiety and more-so paranoia seems to have increased significantly after hosting. Its a strange feeling but I "feel" like its the worms interacting with me somehow.
I had a major increase in anxiety when I started
whipworm (
TT). But with
hookworm my anxiety has improved greatly. I terminated the
whipworm after 6 or 8 weeks when my reaction to them still hadn't eased, so I can't say if that feeling would have persisted or eventually passed.
I am very thankful that I only had 3
NA For my first dose. I am almost done with the week five, and the anxiety I am feeling is truly challenging me.
[23]If anxiety does arise, or worsen, after introducing helminths, this should eventually resolve along with any other symptoms that appear during the initial side effect period. Resolution is usually complete by the end of the 14th week and, if it recurs at all following supplementary inoculations, it typically becomes gradually less troublesome over time.
I have severe anxiety, including PTSD & panic attacks etc. When I initially began treating (with
NA) I would notice an increase in anxiety for several days. It would be a bit uncomfortable & high doses of D3, Benadryl, & magnesium would help. I’m honestly not sure when it stopped. Likely when the bounce stopped, so a year in? Now, the opposite occurs and I get very calm & fall asleep after treating. This usually lasts for several days.
[24]In a few rare cases, anxiety can persist for a longer period of time, leading one individual to terminate their colony.
Increase in energy and exuberance the first month, restlessness the second month, worsening anxiety/OCD third and 4th month, increased to day-long panic attacks fifth month. Directly due to
hookworms as symptoms are 90% improved after 3 days of albendazole.
Combining helminth species to treat anxiety and depression[edit | edit source]
Some individuals have found that a combination of helminth species has given them the best longterm effects.
For me,
TSO plus
NA is the magic combo for anxiety and depression.
[25] Has not been hospitalized in 9 months. Has dropped medications 50%. Looks better, bright eyes. Energy. Hopefulness. Pleasure in life. (After one year of treating with
NA.)[
[26]]
HDC has been found to help in several cases of bipolar disorder.
And there are further reports of success with this disorder in the following paper.
