Helminthic therapy and neurological disorders

    From Helminthic Therapy wiki

    Neurological disorders are any disorders of the nervous system.

    General reviews[edit | edit source]

    See also

    Negative effects

    Brain ischemia-reperfusion injury (IRI)[edit | edit source]

    Reperfusion injury, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia).

    See Helminthic therapy and cardiometabolic conditions: Ischemia-reperfusion injury (IRI)

    Epilepsy[edit | edit source]

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    The Th17/Treg balance is essential for immune homeostasis in the brain. While Th17 cells are proinflammatory and neurotoxic, Treg (CD4+Foxp3+) lymphocytes exert immunosuppressive effects that limit excessive inflammation and maintain tolerance. In epileptic conditions, this balance shifts toward Th17 predominance, as reflected by decreased Treg frequency and function, reduced FoxP3 expression, and upregulated RORγt-mediated Th17 differentiation.[1]

    Helminths improve the Th17/Tregs ratio and could therefore have an beneficial effect.

    See also

    Gulf War Illness[edit | edit source]

    See Helminthic therapy and ME/CFS

    See also

    Heart failure and cognitive impairment[edit | edit source]

    See also

    Long Covid[edit | edit source]

    See Helminthic therapy and Long COVID

    ME/CFS[edit | edit source]

    See Helminthic therapy and ME/CFS

    Memory disorders[edit | edit source]

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    I’m finding that I have a much improved memory. My thoughts are more clear & sharp. I'm in less of a fog. I'm retaining more information and able to recall events from the past that I had forgotten.” (Reported only one month after inoculation with NA.) [2]

    Migraine and headaches[edit | edit source]

    See Helminthic therapy and migraine

    Neurofibromatosis type I[edit | edit source]

    Neurofibromatosis type I (NF-1), or von Recklinghausen syndrome, is a neurodevelopmental disorder many individuals with which also experience neuropsychiatric manifestations.

    Neuropathic pain[edit | edit source]

    See also

    Peripheral nerve injury[edit | edit source]

    See also

    Peripheral neuropathy[edit | edit source]

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    I have peripheral neuropathy in my feet, which in my case manifests most strongly as erythromelagia... I got helminthic therapy (hookworm and human whipworm) in spring 2008. Since then I've been experiencing slow but fairly steady improvement. For a long time I had to soak my feet in cool water to interrupt the attacks, a couple of times a day and always several times in the middle of the night. I no longer need to that, and have no trouble sleeping. Had also lost control of the muscles that straighten my toes, and have gotten that ability back... My feet are not 100%. But the improvement has been very pleasing.” (Link expired)
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    I am pleased to report that after two months on the therapy my symptoms are improving and I'm off the prednisone. I had no side effects except a little dizziness the day I applied the patch." (Reported Mar 2013, after only one dose of hookworm larvae.)

    Spinal cord injury[edit | edit source]

    See also

    Stiff-person syndrome (SPS)[edit | edit source]

    See Helminthic therapy and neuromuscular disorders: Stiff-person syndrome (SPS)

    Stroke[edit | edit source]

    See also

    ILC2

    IL-10

    Tregs, Bregs and Foxp3+ macrophages

    Inflammation

    Microbiota-Gut-Brain Axis

    Traumatic brain injury[edit | edit source]

    See also

    See also[edit | edit source]

    The reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat or prevent chronic inflammation, autoimmune disease and other immune-related disorders, including allergy.

    An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. Wikipedia:Helminths

    a change which is a result or consequence of an action or other cause.

    The introduction of an infectious agent into an organism. Helminth inoculation

    the human hookworm, Necator americanus

    The reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat or prevent chronic inflammation, autoimmune disease and other immune-related disorders, including allergy.

    A helminth that lives in the small intestine. Necator americanus (NA) is the only hookworm species used in helminthic therapy. Its microscopic larvae are applied periodically to the skin.

    A helminth with a tapering whiplike body that lives in the colon. In helminthic therapy, the microscopic eggs of either the human Trichuris trichiura (TTO) or pig Trichuris suis (TSO) are taken in a drink.

    The active immature form of an insect, or an animal such as a helminth, which develops from an egg and eventually transforms again into its adult state.

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