Helminthic therapy and neurological disorders

    From Helminthic Therapy wiki

    Neurological disorders are any disorders of the nervous system.

    See

    General reviews[edit | edit source]

    See also

    Epilepsy[edit | edit source]

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    The Th17/Treg balance is essential for immune homeostasis in the brain. While Th17 cells are proinflammatory and neurotoxic, Treg (CD4+Foxp3+) lymphocytes exert immunosuppressive effects that limit excessive inflammation and maintain tolerance. In epileptic conditions, this balance shifts toward Th17 predominance, as reflected by decreased Treg frequency and function, reduced FoxP3 expression, and upregulated RORγt-mediated Th17 differentiation.[1]

    Helminths improve the Th17/Tregs ratio and could therefore have an beneficial effect.

    See also

    Gulf War Illness[edit | edit source]

    See Helminthic therapy and ME/CFS

    See also

    Heart failure cognitive Impairment[edit | edit source]

    See also

    Long Covid[edit | edit source]

    See Helminthic therapy and COVID-19

    Memory disorders[edit | edit source]

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    I’m finding that I have a much improved memory. My thoughts are more clear & sharp. I'm in less of a fog. I'm retaining more information and able to recall events from the past that I had forgotten.” (Reported only one month after inoculation with NA.) [2]

    Migraine and headaches[edit | edit source]

    The scientific evidence

    Treatment: Eleven patients with the diagnosis of refractory chronic migraine. After the run-in period, patient ingested TSO every 2 weeks for 5 month.
    Results: 5 of 11 patients met the primary endpoint (a reduction in moderate or severe headache days by at least 3 per month) (...) 4 of 11 patients did not meet the primary endpoint. 1 patient did not supply data, and another discontinued due to diarrhea. So there is 50% of improvement with TSO.

    See also (not directly related)

    The anecdotal evidence

    The first three reports are more detailed than the quotes that follow them.

    • "To be enjoying not only whole days without any headache, but also entire weeks, is just incredible." [3]
    • “… my daily regimen of panadol and neurofen for headaches has been cut back (actually cannot remember the last time I took neurofen (ibuprofen))…” (Reported in a private message, Dec 2012)
    • “My headaches have nearly vanished…” [4]
    • "Before I started treatment, I was having a 7.0/10 migraine once a week. Now, I am having a 4.5-5.0/10 migraine once a month." Two years later, this individual rated the improvement in his migraines as 75%. (Links expired)
    • "In addition to the reduction in daily, M.E.-related headaches, my migraines are also greatly reduced in both frequency and severity." [5]
    • ☹️ "… I have ~35 HW and they do not lessen my migraines." (Link expired) (NB. This individual may eventually have responded if he'd maintained his colony for longer. A single dose is often insufficient to provide benefits.)
    • "I used to get headaches all time and some migraines, and now I hardly ever get them since I've inoculated almost a year ago. Actually haven't had a single migraine since, come to think of it…" (Reported in a private discussion, Apr 2012)
    • "My migraine does not appear that often anymore and I am able to do some sports again." (Reported in a private message, Jun 2012)
    • “I am still on migraine meds but I was using 4 Maxalt wafers (Rizatriptan benzoate) /week. Now I use about 1 every 7-10 days…” [6]
    • “My good friend Rick was having migraine headaches about 3 - 5 times or even more per week... Then I started to pick up the HDC for him (and) he had about 30 for his first dose. In a couple of days the migraines subsided. Three weeks later he received his second dose; about the same amount. He continued migraine free for three more weeks. This trend continued as long as he got the necessary dose, apparently about 30 every three weeks.” [7]
    • “In 2008, I got sick. Frighteningly sick. I had excruciating head pain that was unlike anything I'd ever experienced… Month after month, I was in unrelenting, blinding pain. I was so exhausted I could barely move… Three day migraines hit me 8-10 times per month. Nausea often made it impossible to eat. I was so exhausted I could barely move from the bed to lie on the couch all day. Some days I couldn't eat meals because I was too tired to chew… As I write this, it is a week short of seven months since I started helminth immune support... Things aren't perfect. A person with normal energy can easily work me into the ground. I still have ​migraines, although they occur less frequently and with lower intensity... (but) ​I started my day with tandem kayaking. After that, I came home, fed and watered the chickens, collected eggs, cooked a hot breakfast, tidied up the kitchen, washed and hung out laundry, attended to some gardening duties and spent several hours designing this new site and writing this page. I'm no longer too tired to chew.” [8]
    • “My wife's allergies got worse and worse over seven years, manifesting in migraines that would last for days. The codeine she took for the pain masked the normal allergy symptoms so we tried endless dead-end therapies. Only after trying HDC has she got rid of her migraines, all her allergies went away.” [9]
    • “I didn’t start HT for migraine in particular, but I actually haven’t had a single migraine attack ever since. (I had migraine on a regular basis for 10 years). So for me it was obviously related to my autoimmune issues.” [10]
    • “My brother in law is treating migraines with NA. He has very severe frequent migraines and relies on injections. Since starting NA he has had a gradual reduction in frequency and severity. It's been about 8 months and he swears by them.” [11]
    • "My son has been hosting NA for years and he experienced lots of health benefits but it has taken a long time to get on top of his migraines. He has found taking around 10 NA every month has stopped them." [12]

    Neurofibromatosis type I[edit | edit source]

    Neurofibromatosis type I (NF-1), or von Recklinghausen syndrome, is a neurodevelopmental disorder many individuals with which also experience neuropsychiatric manifestations.

    Neuropathic pain[edit | edit source]

    See also

    Peripheral nerve injury[edit | edit source]

    See also

    Spinal cord injury[edit | edit source]

    See also

    Stroke[edit | edit source]

    See also

    ILC2

    IL-10

    Tregs, Bregs and Foxp3+ macrophages

    Inflammation

    Microbiota-Gut-Brain Axis

    Traumatic brain injury[edit | edit source]

    See also

    See also[edit | edit source]

    The reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat or prevent chronic inflammation, autoimmune disease and other immune-related disorders, including allergy.

    An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. Wikipedia:Helminths

    a change which is a result or consequence of an action or other cause.

    The introduction of an infectious agent into an organism. Helminth inoculation

    the human hookworm, Necator americanus

    the ova (eggs) of the porcine (pig) whipworm, Trichuris suis

    hookworm, usually referring to the human hookworm, Necator americanus

    Hymenolepis diminuta cysticercoids (Hi-men-o-lep'is dim-a-nu-ta sis-ti-sur-koid) - the larval cysts of the rat tapeworm, Hymenolepis diminuta

    An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. Wikipedia:Helminths

    helminthic therapy

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