Helminthic therapy and neurodevelopmental disorders
Neurodevelopmental disorders are a group of mental conditions negatively affecting the development of the nervous system, which includes the brain and spinal cord. Key features of these conditions are:
- Start early in life (often noticeable in childhood)
- Affect how the brain develops and organizes itself
- Often involve learning, communication, attention or social functioning
- Tend to be lifelong, though symptoms can change over time
Common examples of neurodevelopmental disorder are: autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), intellectual disability, specific learning disorders (such as dyslexia) and developmental language disorder.
Scientific papers[edit | edit source]
- 2026 Feb 28 Zero Prevalence of Soil-Transmitted Helminth Infections among Students with Disabilities and Symptoms of Attention-Deficit/Hyperactivity Disorder in Bengkulu City, Indonesia
- 2026 Jan 14 Rethinking ADHD as a neurointestinal syndrome: a gut-brain-parasite hypothesis -- Full text | PDF
- ✅ 2024 Oct 22 The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring -- Full text
- 2024 Jun Maternal gastrointestinal nematode infection alters hippocampal neuroimmunity, enhances long-term potentiation and spatial memory and improves resistance to direct infection in mouse offspring -- PDF (Thesis)
- 2024 Jun Gastrointestinal nematode infection during pregnancy and lactation enhances spatial reference memory and reduces indicators of anxiety-like behaviour in uninfected adult female mouse offspring -- Full text | PDF
- 2024 May 10 Maternal gastrointestinal nematode infection alters hippocampal neuroimmunity, promotes synaptic plasticity, and improves resistance to direct infection in offspring -- Full text | PDF
- 2022 Jun 13 Maternal gastrointestinal nematode infection enhances spatial memory of uninfected juvenile mouse pups -- Full text | PDF
- 2021 Nov 11 Maternal nematode infection upregulates expression of Th2/Treg and diapedesis related genes in the neonatal brain
- 2021 Jan Upregulated Th2/treg brain gene expression in pups of nematode-infected mice associated with enhanced expression of leukocyte trans-endothelial cell migration across the blood brain barrier -- PDF (Thesis)
- 2020 Sep Maternal nematode infection alters neonatal brain gene expression and maternal and neonatal microbiomes -- PDF (Thesis)
- 2019 Mar 12 Maternal Gastrointestinal Nematode Infection Up-regulates Expression of Genes Associated with Long-Term Potentiation in Perinatal Brains of Uninfected Developing Pups
in seven-day old pups, long-term potentiation and four related pathways essential for the development of synaptic plasticity, cognition and memory were up-regulated
- 2018 Sep 25 Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats
- 2015 Jul 7 Got Worms? Perinatal Exposure to Helminths Prevents Persistent Immune Sensitization and Cognitive Dysfunction Induced by Early-Life Infection -- pdf (see also The “Old Friends” hypothesis: Reopening a can of worms)
For more papers, see
[edit | edit source]
Various[edit | edit source]
- 2026 Jan 6 The lifespan continuum of brain disorders: investigating links between neurodevelopmental and neurodegenerative disease-chicken or egg?
- 2025 Dec Maternal Obesity in Pregnancy: Risk Factor for Neurodevelopmental Outcomes in Offspring -- Full text | PDF
- 2025 Nov 20 The critical role of Th17 cells and IL-17A in autoimmune and inflammation-associated neurological diseases: mechanisms and therapeutic perspectives -- Full text | PDF
- 2025 Nov 19 The impact of trans fatty acids on ADHD in relation to the gut microbiome -- Full text | PDF
- 2025 Jul 1 Maternal immune-mediated conditions and ADHD risk in offspring
More papers (Tap to expand / minimize)
- 2025 Jun 23 Group 2 innate lymphoid cells drive inhibitory synapse formation with lasting effects on learning and memory -- Full text | PDF
- 2025 Jan A microglia-containing cerebral organoid model to study early life immune challenges
- 2024 Nov Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior -- Full text | PDF
- 2024 Jul 11 Antibiotic use and risk of autism spectrum disorder and attention-deficit/hyperactivity disorder: a population-based cohort study
- 2023 May Maternal and Early-Life Exposure to Antibiotics and the Risk of Autism and Attention-Deficit Hyperactivity Disorder in Childhood: a Swedish Population-Based Cohort Study
- 2023 Jan 10 Anti-inflammatory properties of commonly used psychiatric drugs
- 2023 Mast Cell Modulation of the Developing Hippocampus (Thesis, Maryland)
- 2022 Aug 2 Prenatal environmental stressors impair postnatal microglia function and adult behavior in males
- 2017 Dec 4 Selective proliferative response of microglia to alternative polarization signals
Maternal immune activation[edit | edit source]
- 2026 Feb 3 Maternal-fetal immune conflict contributes to male-specific impairments in a mouse model of neurodevelopmental disorders (Preprint)
- 2026 Feb 1 Sex specific effects of adoptive Tregs transfer on the brain and periphery in maternal immune activation offspring rescuing immune dysregulation (Preprint)
- 2026 Feb Maternal immune activation during gestation modulates offspring immune profiles in a nonhuman primate model
- 2026 Jan 24 Maternal Poly (I:C)-Induced Placental Inflammation and Endocrine Dysfunction Are Associated with Disrupted Corticogenesis in Mouse Offspring
- 2025 Nov 24 Maternal Immune Activation and Neurodevelopmental Disorders: Integrating Molecular, Cellular and Systems Mechanisms -- Full text | PDF
More papers (Tap to expand / minimize)
- 2025 Nov 16 Double-hit of MIA and Nod2 deficiency induces sex-specific offspring behavioral abnormalities through placental dysregulation
- 2025 Jul Neuroimmune and behavioral changes elicited by maternal immune activation in mice are ameliorated by early postnatal immune stimulation
- 2024 Oct Prenatal drivers of microglia vulnerability in the adult
- 2024 Oct Altered brain metabolites in male nonhuman primate offspring exposed to maternal immune activation
- 2025 Jul 28 Maternal immune activation alters infant attentional processing in a nonhuman primate model
- 2024 Jul 11 The role of microglia in early neurodevelopment and the effects of maternal immune activation
- 2024 May 7 Impact of maternal immune activation and sex on placental and fetal brain cytokine and gene expression profiles in a preclinical model of neurodevelopmental disorders
- 2023 Aug 15 The Outcomes of Maternal Immune Activation Induced with the Viral Mimetic Poly I:C on Microglia in Exposed Rodent Offspring
- 2023 Feb Maternal behaviours and adult offspring behavioural deficits are predicted by maternal TNFα concentration in a rat model of neurodevelopmental disorders
- 2022 Oct Immune Activation in Pregnant Rats Affects Brain Glucose Consumption, Anxiety-like Behaviour and Recognition Memory in their Male Offspring
- 2022 Sep 15 Impact of Maternal Immune Activation on Nonhuman Primate Prefrontal Cortex Development: Insights for Schizophrenia
- 2022 Jan Emerging evidence of Toll-like receptors as a putative pathway linking maternal inflammation and neurodevelopmental disorders in human offspring: A systematic review
- 2021 Dec 1 Maternal Immune Activation during Pregnancy Alters Postnatal Brain Growth and Cognitive Development in Nonhuman Primate Offspring
- 2021 Jun Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal Treg cells
- 2021 Apr 23 Mycobacterium tuberculosis-Induced Maternal Immune Activation Promotes Autism-Like Phenotype in Infected Mice Offspring
- 2021 Jan 21 Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review
- 2018 Apr Microglia, the missing link in maternal immune activation and fetal neurodevelopment; and a possible link in preeclampsia and disturbed neurodevelopment?
- 2018 Jan Maternal IL-17A in autism
- 2017 Jul Long-term altered immune responses following fetal priming in a non-human primate model of maternal immune activation
- 2014 May Maternal immune activation leads to activated inflammatory macrophages in offspring
Group B Streptococcus-Induced Chorioamnionitis[edit | edit source]
- 2025 Aug 1 Restricted fetal blood brain barrier permeability in a preclinical model of autism induced by Group B Streptococcus maternal immune activation
- 2025 Jul 2 Group B Streptococcus disease during infancy and risk of subsequent neurodevelopmental impairments in young children: a population-based cohort study in Ontario, Canada
- 2024 Oct 23 IL-1 Blockade Mitigates Autism and Cerebral Palsy Traits in Offspring In-Utero Exposed to Group B Streptococcus Chorioamnionitis
- 2023 Sep 14 Sex-Specific Dysconnective Brain Injuries and Neuropsychiatric Conditions such as Autism Spectrum Disorder Caused by Group B Streptococcus-Induced Chorioamnionitis
Microbiota Gut-Brain Axis[edit | edit source]
- 2026 Feb 15 Gut virome plays an extended role with bacteriome in neurological health and disease (also [https://doi.org/10.22541/au.175983852.28276315/v1 preprint)
- 2026 Jan 23 Intergenerational effects of the microbiota on neurodevelopment: mechanisms and therapeutic perspectives
- 2026 Jan Microbiome dynamics in attention-deficit hyperactivity disorder: A systematic review and meta-analysis decoding the role of gut dysbiosis and potential dietary interventions
- 2025 Dec Symptom-specific gut microbial and metabolic profiles in ADHD reveal SCFA deficiency as a Key pathogenic mechanism -- Full text | PDF
- 2025 Nov 26 Gut Microbiota and Autism: Unlocking Connections
More papers (Tap to expand / minimize)
- 2025 Nov 17 The Pediatric Microbiota-Gut-Brain Axis: Implications for Neuropsychiatric Development and Intervention
- 2025 Nov Gut Microbiota-Derived Short-Chain Fatty Acids and Sleep Disturbances in Pediatric Attention-Deficit/Hyperactivity Disorder: Insights Into Neurobiological Links and Treatment Implications
- 2025 Nov Role of the gut-brain axis in neurological diseases: Molecular connections and therapeutic implications (Review)
- 2025 Sep 17 Microbiota Gut-Brain Axis and Autism Spectrum Disorder: Mechanisms and Therapeutic Perspectives
- 2025 Sep The Microbiota-Gut-Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders
- 2025 Aug 29 Gut Microbiota in Psychiatric and Neurological Disorders: Current Insights and Therapeutic Implications
- 2025 Jul 28 Impact of maternal microbiota imbalance during pregnancy on fetal cerebral neurodevelopment: Is there a link to certain autistic disorders?
- 2025 Jul 2 Disruption of gut microbiome and metabolome in treatment-naïve children with attention deficit hyperactivity disorder
- 2025 Jun Gut microbiome differences in children with Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder and effects of probiotic supplementation: A randomized controlled trial
- 2025 May 23 A narrative review of research advances in gut microbiota and microecological agents in children with attention deficit hyperactivity disorder (ADHD)
- 2025 May 19 Gut-Brain Inflammatory Pathways in Attention-Deficit/Hyperactivity Disorder: The Role and Therapeutic Potential of Diet
- 2025 Apr 8 Exploring the Gut-brain Axis: Microbiome Contributions to Pathophysiology of Attention Deficit Hyperactivity Disorder and Potential Therapeutic Strategies
- 2025 Apr Common Gut Microbial Signatures in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder
- 2025 Mar 17 Gut dysbiosis as a driver of neuroinflammation in attention-deficit/hyperactivity disorder: A review of current evidence
- 2024 Dec 23 Beyond the Brain: Attention Deficit/Hyperactivity Disorder and the Gut-Brain Axis
- 2024 Jul 27 Disrupted gut harmony in attention-deficit/hyperactivity disorder: Dysbiosis and decreased short-chain fatty acids
- 2024 Nov The gut-microbiome in adult Attention-deficit/hyperactivity disorder - A Meta-analysis
- 2023 Jan-Dec Children and adolescents with attention deficit hyperactivity disorder and autism spectrum disorder share distinct microbiota compositions
- 2020 Jul Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders
- 2020 Apr 1 Gut microbiota from persons with attention-deficit/hyperactivity disorder affects the brain in mice
- 2020 Feb 18 Case-Control Study of the Effects of Gut Microbiota Composition on Neurotransmitter Metabolic Pathways in Children With Attention Deficit Hyperactivity Disorder
Autism[edit | edit source]
See Helminthic therapy and autism
Attention deficit hyperactivity disorder (ADHD, ADD)[edit | edit source]
- 2026 Jan 14 Rethinking ADHD as a neurointestinal syndrome: a gut-brain-parasite hypothesis -- Full text | PDF
- 2025 Dec Symptom-specific gut microbial and metabolic profiles in ADHD reveal SCFA deficiency as a Key pathogenic mechanism -- Full text | PDF
- 2025 Nov 19 The impact of trans fatty acids on ADHD in relation to the gut microbiome -- Full text | PDF
Personal story:
Neurofibromatosis type I[edit | edit source]
See Helminthic therapy and neurological disorders
Tourette Syndrome[edit | edit source]
See Helminthic therapy and neuropsychiatric disorders: Tourette Syndrome