Helminthic therapy and osteoporosis
Osteoporosis is a metabolic bone disease - a systemic skeletal disorder characterized by low bone mass (osteopenia) and more porous bone. It commonly affects older adults, particularly postmenopausal women, and involves the progressive deterioration of bone tissue over time with a consequent increase in the risk of fractures.
Osteoporosis has no symptoms, and a person usually does not know they have the disorder until a bone breaks. It is also more prevalent among the elderly who are statistically less likely to be aware of helminthic therapy and open to using it, factors which may partly explain why there have been no reports to date from individuals with osteoporosis about their use of helminthic therapy.
The scientific evidence[edit | edit source]
- 2025 Nov Clonorchis sinensis Crude Antigen Suppresses Osteoclast Differentiation via Modulation of the NF-κB and MAPK Signaling Pathway -- Full text | PDF
- 2022 Jan 20 Inflammatory Arthritis and Bone Metabolism Regulated by Type 2 Innate and Adaptive Immunity
- 2017 Oct 16 Is osteoporosis an autoimmune mediated disorder? -- Full text | PDF
- 2017 Jan 13 Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites
See also
- 2026 Feb 19 Macrophage polarization: A bridge connecting osteoarthritis and osteoporosis
- 2025 Dec Interactions between the gut microbiota and immune cell dynamics: novel insights into the gut-bone axis
- 2025 Nov 24 Functional roles of immune cells in osteoporosis
- 2025 Oct 2 Immune cells: the key mediator between the gut microbiota and osteoporosis
- 2025 Sep 1 The gut microbiota in osteoporosis: dual roles and therapeutic prospects
- 2025 Aug 18 Adipokines and Associations With Incident Osteoporotic Fracture in Patients With Rheumatoid Arthritis
- 2025 Aug 14 Causal Associations of the Alterations in Peripheral Blood Immune Cell Characteristics on the Incidence of Osteoporosis: A Bidirectional Mendelian Randomization Study
- 2025 Jul 25 Immunoporosis: The hidden link between aging immune cells and bone fragility
- 2025 May 22 Deciphering the gut microbiome's metabolic code: pathways to bone health and novel therapeutic avenues
- 2025 Apr 10 Osteoimmunology: Crosstalk Between T Cells and Osteoclasts in Osteoporosis
- 2025 Apr 4 Emerging Roles of Eosinophils in Bone
- 2024 Dec Contribution of macrophage polarization in bone metabolism: A literature review
- 2024 Sep 4 Emerging role of liver-bone axis in osteoporosis
- 2024 May 16 Osteoporosis: interferon-gamma-mediated bone remodeling in osteoimmunology
- 2024 Feb 5 Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase
- 2023 Dec Inflammatory Processes Affecting Bone Health and Repair
- 2022 Jun 6 Insights into the Role of Macrophage Polarization in the Pathogenesis of Osteoporosis
- 2022 Mar 5 The Rising Era of "Immunoporosis": Role of Immune System in the Pathophysiology of Osteoporosis
- 2022 Mar Interaction between bone and immune cells: Implications for postmenopausal osteoporosis
- 2021 Jul 7 Role of Short Chain Fatty Acids on systemic bone density and their protective effects on pathological bone loss (Thesis, Erlangen-Nürnberg)
- 2021 May 25 Systemic NF-κB-mediated inflammation promotes an aging phenotype in skeletal stem/progenitor cells
- 2020 Aug Two adipocytokines, leptin and adiponectin, independently predict osteoporotic fracture risk at different bone sites in postmenopausal women
- 2020 Sep 30 Macrophage Polarization and Osteoporosis: A Review
- 2019 Apr 2 Age-related inflammation triggers skeletal stem/progenitor cell dysfunction (Press coverage 2019 Mar 18 'Inflamm-aging' causes loss of bone healing ability in the elderly
- Age-associated inflammation is responsible for the decline in the number and function of the skeletal stem cells that enable bones to heal.
- 2018 Jun High-Fat Diet-Induced Obesity Promotes Expansion of Bone Marrow Adipose Tissue and Impairs Skeletal Stem Cell Functions in Mice
- 2018 Feb 7 Regulation of Osteoclast Differentiation by Cytokine Networks
- 2016 Jul Preclinical assessment of the influence of inflammation on bone regeneration (Thesis)
- 2010 Oct Novel functions for NFκB: inhibition of bone formation
- 2009 Oct 13 The Role of Regulatory T Cells in Bone Homeostasis (Thesis, Erlangen-Nürnberg)
Helminths that promote bone loss