Helminthic therapy and cystic fibrosis

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Cystic fibrosis (CF) is a systemic genetic disorder affecting multiple body systems, with the lungs being the organ system most significantly impacted.

Since it is a genetic, rather than an immune-related disorder, helminths might appear to have little if any role in its treatment. However, CF patients can experience chronic inflammation that can cause lung damage. [1] As helminths are very effective controllers of inflammation, they may, after all, have a role in helping to improve quality of life for CF patients.

The airways of CF patients can also produce thick, abnormal mucus which can promote infection and make its treatment more difficult. This feature may be something else with which helminthic therapy could help.

See also

• 2022 Apr 28 Characterization of human blood type-2 innate lymphoid cells in cystic fibrosis lung disease

Alternative treatment option

• 1998 Aug Activation of ΔF508 CFTR in an epithelial monolayer — Full text

DMSO might be helpful in cystic fibrosis by acting as a "chemical chaperone" to transport functional CTFR proteins to the cell membrane.

The reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat or prevent chronic inflammation, autoimmune disease and other immune-related disorders, including allergy.

An intestinal worm which grows large enough to be seen with the naked eye when mature but which is microscopic when administered in helminthic therapy. Wikipedia:Helminths

The reintroduction to the digestive tract of a controlled number of specially domesticated, mutualistic helminths (intestinal worms) in the form of microscopic eggs or larvae to reconstitute a depleted biome to treat or prevent chronic inflammation, autoimmune disease and other immune-related disorders, including allergy.