Helminthic Therapy wiki - Recent changes [en]

Self-treating with HDC

John — Thu, 30 Apr 2026 16:36:33 GMT

Storage and survival of HDC

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	== Storage and survival of HDC ==		== Storage and survival of HDC ==

	HDC experience a gradual and continuous decline from the moment they are extracted from their intermediate (beetle) host ~~and, even~~ if they are placed in a saline solution, only 60% will survive for 24 hours, and none for more than 48 hours. Therefore, doses of '''''fresh''''' HDC should be taken as soon as possible, ideally immediately after extraction, but definitely within 24 hours of being harvested - not 24 hours after receipt by a customer.		HDC experience a gradual and continuous decline from the moment they are extracted from their intermediate (beetle) host until they enter a new host. Even if they are placed in a saline solution, only 60% will survive for 24 hours, and none for more than 48 hours. Therefore, doses of '''''fresh''''' HDC should be taken as soon as possible, ideally immediately after extraction, but definitely within 24 hours of being harvested - not 24 hours after receipt by a customer.

	The '''''commercially prepared''''' HDC supplied by [http://www.biomerestoration.com Biome Restoration] will survive for 2 to 3 weeks as a result of being stored in a nutrient solution developed specially for this species by this company. HDC from this source are usually received within 11 days of being shipped, and must then be used immediately or refrigerated for up to 2 weeks at 4ºC (39-40ºF). There is anecdotal evidence that a shorter storage period is likely to result in a better immune response to the HDC.		The '''''commercially prepared''''' HDC supplied by [http://www.biomerestoration.com Biome Restoration] will survive for 2 to 3 weeks as a result of being stored in a nutrient solution developed specially for this species by this company. HDC from this source are usually received within 11 days of being shipped, and must then be used immediately or refrigerated for up to 2 weeks at 4ºC (39-40ºF). There is anecdotal evidence that a shorter storage period is likely to result in a better immune response to the HDC.

Helminthic therapy and inflammatory bowel disease (IBD)

Jlm — Thu, 30 Apr 2026 16:17:51 GMT

More scientific studies

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	* 2026 Apr 30 [https://pubmed.ncbi.nlm.nih.gov/41984489/ Helminth Excretory/Secretory Proteins Ameliorate Colitis Through Preservation of Intestinal Homeostasis]		* 2026 Apr 30 [https://pubmed.ncbi.nlm.nih.gov/41984489/ Helminth Excretory/Secretory Proteins Ameliorate Colitis Through Preservation of Intestinal Homeostasis]

	* 2026 Apr 13 [https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1767639/abstract Helminth exposure influences Th17 plasticity, suppressing inflammatory and promoting regulatory activity by Th17 lineage cells] ~~(Online ahead of print)~~		* 2026 Apr 28 [https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1767639/abstract Helminth exposure influences Th17 plasticity, suppressing inflammatory and promoting regulatory activity by Th17 lineage cells]

	* 2026 Feb 23 [https://pubmed.ncbi.nlm.nih.gov/41808832/ Trichuris suis ova in inflammatory bowel disease-clinical challenges and translational pathways]		* 2026 Feb 23 [https://pubmed.ncbi.nlm.nih.gov/41808832/ Trichuris suis ova in inflammatory bowel disease-clinical challenges and translational pathways]

Helminthic therapy and allergy

Jlm — Thu, 30 Apr 2026 11:32:20 GMT

Helminths that promote allergies

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	* 2020 [https://pubmed.ncbi.nlm.nih.gov/31284858/ Allergen-like Molecules from Parasites]		* 2020 [https://pubmed.ncbi.nlm.nih.gov/31284858/ Allergen-like Molecules from Parasites]
	* 2018 Jan [https://pubmed.ncbi.nlm.nih.gov/29117468/ Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway]		* 2018 Jan [https://pubmed.ncbi.nlm.nih.gov/29117468/ Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway]
			* 2010 May [https://pubmed.ncbi.nlm.nih.gov/20500664/ Parasite excretory-secretory proteins elicit TRIF dependent CXCL1 and IL-6 mediated allergic inflammation]

	== Clinical Trials and observational studies ==		== Clinical Trials and observational studies ==

Mechanisms underlying helminth colonization

Jlm — Thu, 30 Apr 2026 11:31:55 GMT

IL-6

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	* 2010 Jul [https://pubmed.ncbi.nlm.nih.gov/20404082/ Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC2897394/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC2897394/pdf/1228-09.pdf PDF]		* 2010 Jul [https://pubmed.ncbi.nlm.nih.gov/20404082/ Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC2897394/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC2897394/pdf/1228-09.pdf PDF]

			2010 May [https://pubmed.ncbi.nlm.nih.gov/20500664/ Parasite excretory-secretory proteins elicit TRIF dependent CXCL1 and IL-6 mediated allergic inflammation]

	* 2010 Mar [https://pubmed.ncbi.nlm.nih.gov/19691904/ The immune response to and immunomodulation by Hymenolepis diminuta]		* 2010 Mar [https://pubmed.ncbi.nlm.nih.gov/19691904/ The immune response to and immunomodulation by Hymenolepis diminuta]
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	* 2014 Jan [https://pubmed.ncbi.nlm.nih.gov/24185641/ IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3992848/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC3992848/pdf/eji0044-0150.pdf PDF]		* 2014 Jan [https://pubmed.ncbi.nlm.nih.gov/24185641/ IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3992848/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC3992848/pdf/eji0044-0150.pdf PDF]
	* 2013 Nov 20 [https://bonndoc.ulb.uni-bonn.de/xmlui/handle/20.500.11811/5797 Role of interleukin-6 during infection with the filarial nematode Litomosoides sigmodontis] (Thesis, Bonn)		* 2013 Nov 20 [https://bonndoc.ulb.uni-bonn.de/xmlui/handle/20.500.11811/5797 Role of interleukin-6 during infection with the filarial nematode Litomosoides sigmodontis] (Thesis, Bonn)
			* 2010 May [https://pubmed.ncbi.nlm.nih.gov/20500664/ Parasite excretory-secretory proteins elicit TRIF dependent CXCL1 and IL-6 mediated allergic inflammation]
	* 2005 Aug 10 [https://pubmed.ncbi.nlm.nih.gov/15978725/ Trichuris suis excretory secretory products (ESP) elicit interleukin-6 (IL-6) and IL-10 secretion from intestinal epithelial cells (IPEC-1)]		* 2005 Aug 10 [https://pubmed.ncbi.nlm.nih.gov/15978725/ Trichuris suis excretory secretory products (ESP) elicit interleukin-6 (IL-6) and IL-10 secretion from intestinal epithelial cells (IPEC-1)]

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	* 2013 [https://pubmed.ncbi.nlm.nih.gov/25383073/ Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4223871/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4223871/pdf/nihms563850.pdf PDF]		* 2013 [https://pubmed.ncbi.nlm.nih.gov/25383073/ Role of Chemokines and Trafficking of Immune Cells in Parasitic Infections] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4223871/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4223871/pdf/nihms563850.pdf PDF]
	* 2010 Aug [https://digital.library.adelaide.edu.au/items/6e30f900-3003-40e7-b068-aa4f45961357 Host-parasite interactions in primary and secondary infections with Nippostrongylus brasiliensis and Heligmosomoides bakeri] (Thesis)		* 2010 Aug [https://digital.library.adelaide.edu.au/items/6e30f900-3003-40e7-b068-aa4f45961357 Host-parasite interactions in primary and secondary infections with Nippostrongylus brasiliensis and Heligmosomoides bakeri] (Thesis)
			* 2010 May [https://pubmed.ncbi.nlm.nih.gov/20500664/ Parasite excretory-secretory proteins elicit TRIF dependent CXCL1 and IL-6 mediated allergic inflammation]
	* 2010 [https://espace.library.uq.edu.au/view/UQ:205370 Transcriptomics of Schistosoma japonicum-induced immunopathology] (Thesis, Queensland)		* 2010 [https://espace.library.uq.edu.au/view/UQ:205370 Transcriptomics of Schistosoma japonicum-induced immunopathology] (Thesis, Queensland)
	* 2009 Aug [https://pubmed.ncbi.nlm.nih.gov/19535141/ The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri] -- [https://openresearch-repository.anu.edu.au/server/api/core/bitstreams/fe2c741a-90fe-41f5-b5d4-94359eb317ea/content PDF]		* 2009 Aug [https://pubmed.ncbi.nlm.nih.gov/19535141/ The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri] -- [https://openresearch-repository.anu.edu.au/server/api/core/bitstreams/fe2c741a-90fe-41f5-b5d4-94359eb317ea/content PDF]

Helminthic therapy and coeliac / celiac disease

Jlm — Thu, 30 Apr 2026 09:53:26 GMT

The scientific evidence

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	See also		See also

			* 2026 Apr [https://pubmed.ncbi.nlm.nih.gov/42033586/ Upcoming Treatments in Celiac Disease: From Luminal Enzymes to Oral Immune Tolerance]
	* 2026 [https://kaznmu.edu.kz/wp-content/uploads/2025/12/%D0%94%D0%B8%D1%81%D1%81%D0%B5%D1%80%D1%82%D0%B0%D1%86%D0%B8%D1%8F_%D0%9A%D0%B0%D0%BF%D0%B0%D1%81%D0%BE%D0%B2%D0%BE%D0%B9-%D0%90.%D0%A2-2.pdf Features of the diagnosis and clinical course of celiac disease in patients in the Republic of Kazakhstan] (Thesis, Russian)		* 2026 [https://kaznmu.edu.kz/wp-content/uploads/2025/12/%D0%94%D0%B8%D1%81%D1%81%D0%B5%D1%80%D1%82%D0%B0%D1%86%D0%B8%D1%8F_%D0%9A%D0%B0%D0%BF%D0%B0%D1%81%D0%BE%D0%B2%D0%BE%D0%B9-%D0%90.%D0%A2-2.pdf Features of the diagnosis and clinical course of celiac disease in patients in the Republic of Kazakhstan] (Thesis, Russian)
	* 2025 Sep [https://pubmed.ncbi.nlm.nih.gov/40936207/ Children With Celiac Disease Have a Higher Degree of Activated or Exhausted CD4+ and CD8+ T Cells Compared to Healthy References] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12426357/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12426357/pdf/SJI-102-e70054.pdf PDF]		* 2025 Sep [https://pubmed.ncbi.nlm.nih.gov/40936207/ Children With Celiac Disease Have a Higher Degree of Activated or Exhausted CD4+ and CD8+ T Cells Compared to Healthy References] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC12426357/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC12426357/pdf/SJI-102-e70054.pdf PDF]

Mechanisms underlying helminth colonization

Jlm — Thu, 30 Apr 2026 09:49:23 GMT

Tuft cells

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	* 2026 Mar 27 [https://pubmed.ncbi.nlm.nih.gov/41903550/ Tuft cells promote reactivation of memory Th2 cells and are required for protective immunity to intestinal helminth re-infection] (Online ahead of print)		* 2026 Mar 27 [https://pubmed.ncbi.nlm.nih.gov/41903550/ Tuft cells promote reactivation of memory Th2 cells and are required for protective immunity to intestinal helminth re-infection] (Online ahead of print)
	* 2026 Mar 25 [https://pubmed.ncbi.nlm.nih.gov/41882357/ Parasites trigger epithelial cell crosstalk to drive gut-brain signalling] (Nature)		* 2026 Mar 25 [https://pubmed.ncbi.nlm.nih.gov/41882357/ Parasites trigger epithelial cell crosstalk to drive gut-brain signalling] (Nature)
	* 2026 Feb 25 [https://pubmed.ncbi.nlm.nih.gov/41739917/ KIT supports small intestinal tuft cell hyperplasia]		* 2026 Feb 27 [https://pubmed.ncbi.nlm.nih.gov/41739917/ KIT supports small intestinal tuft cell hyperplasia]
	* 2025 Oct 22 [https://www.zora.uzh.ch/entities/publication/3aa07d73-b6d7-4607-b566-a26d00832081 Tissue Adaptations of the Small Intestine During Helminth Infection] (Thesis)		* 2025 Oct 22 [https://www.zora.uzh.ch/entities/publication/3aa07d73-b6d7-4607-b566-a26d00832081 Tissue Adaptations of the Small Intestine During Helminth Infection] (Thesis)
	* 2025 Oct [https://www.ijtsrd.com/papers/ijtsrd97634.pdf Immunoepithelial Crosstalk in Regeneration: The Emerging Role of Tuft Cells: A Review]		* 2025 Oct [https://www.ijtsrd.com/papers/ijtsrd97634.pdf Immunoepithelial Crosstalk in Regeneration: The Emerging Role of Tuft Cells: A Review]

Human helminth care manual

John — Thu, 30 Apr 2026 02:23:48 GMT

❓ More antifungals

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	* ⚡ [https://en.wikipedia.org/wiki/Curcumin Curcumin] inhibits candida [http://jac.oxfordjournals.org/content/63/2/337.long], even at low concentrations, but see the main entry below for [[#Turmeric\|Turmeric/curcumin]] for further details.		* ⚡ [https://en.wikipedia.org/wiki/Curcumin Curcumin] inhibits candida [http://jac.oxfordjournals.org/content/63/2/337.long], even at low concentrations, but see the main entry below for [[#Turmeric\|Turmeric/curcumin]] for further details.
	<span id="Black cumin"></span>		<span id="Black cumin"></span>
	* ❌ [https://en.wikipedia.org/wiki/Nigella_sativa Black cumin] (nigella sativa). Also known as blackseed, black seed, black caraway, fennel-flower, nutmeg flower, Roman coriander, kalonji and 'Love in the Mist'. Extracts of this herb have shown antifungal effects [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642442/] against different strains of Candida albicans, but it has also been used as an anthelmintic since ancient times. In India, today, nigella seeds are combined with various purgatives to help kill and expel intestinal parasites, and they have a synergistic effect with pharmaceutical anthelmintics. [https://www.ncbi.nlm.nih.gov/pubmed/30149818]		* ❌ [https://en.wikipedia.org/wiki/Nigella_sativa Black cumin] (nigella sativa). Also known as blackseed, black seed, black caraway, fennel-flower, nutmeg flower, Roman coriander, kalonji and 'Love in the Mist'. Extracts of this herb have shown antifungal effects [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642442/] against different strains of Candida albicans, but it has also been used as an anthelmintic since ancient times. While one self-treater has reported that black cumin did not harm NA, HDC or TSO when he took them, [https://www.facebook.com/groups/htsupport/permalink/26499688856327052/] black cumin and its active component, thymoquinone, have nevertheless demonstrated anthelmintic activity against several nematode species, including Trichuris muris - a relative of the human whipworm, Trichuris trichiura - as well as two other human helminths: Ascaris lumbricoides and the blood fluke, Schistosoma mansoni. In India, today, nigella seeds are combined with various purgatives to help kill and expel intestinal parasites, and they have a synergistic effect with pharmaceutical anthelmintics. [https://www.ncbi.nlm.nih.gov/pubmed/30149818]

	* ❌ [https://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre] is effective against candida [http://www.k-state.edu/media/newsreleases/jun13/vediyappan91213.html], but hydroalcoholic extracts of this herb have been found to have anthelmintic activity against the Indian earthworm, Pheretima posthuma. [http://www.ijrap.net/admin/php/uploads/525_pdf.pdf] Even though the research worm, C. elegans, appears to be unaffected by gymnema [http://www.ncbi.nlm.nih.gov/pubmed/?term=gymnema+sylvestre+candida] and there are genetic similarities [http://www.ncbi.nlm.nih.gov/pubmed/11812491] between C. elegans and N. americanus, one helminth host suspects that gymnema was responsible for the loss of his hookworm colony.		* ❌ [https://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre] is effective against candida [http://www.k-state.edu/media/newsreleases/jun13/vediyappan91213.html], but hydroalcoholic extracts of this herb have been found to have anthelmintic activity against the Indian earthworm, Pheretima posthuma. [http://www.ijrap.net/admin/php/uploads/525_pdf.pdf] Even though the research worm, C. elegans, appears to be unaffected by gymnema [http://www.ncbi.nlm.nih.gov/pubmed/?term=gymnema+sylvestre+candida] and there are genetic similarities [http://www.ncbi.nlm.nih.gov/pubmed/11812491] between C. elegans and N. americanus, one helminth host suspects that gymnema was responsible for the loss of his hookworm colony.

Helminthic Therapy Wiki

John — Thu, 30 Apr 2026 01:10:09 GMT

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	This is a collaborative, crowd-sourced site administered by volunteers presenting the extensive research supporting this practice, along with over a thousand personal stories demonstrating it's effects, plus tips to help manage the therapy and optimise its benefits.		This is a collaborative, crowd-sourced site administered by volunteers presenting the extensive research supporting this practice, along with over a thousand personal stories demonstrating it's effects, plus tips to help manage the therapy and optimise its benefits.

			All writing and editing on this site is done by humans.
	</div> <!-- End Desc Col -->		</div> <!-- End Desc Col -->
	<!--		<!--

Helminth providers

John — Wed, 29 Apr 2026 22:56:44 GMT

Help with using Bitcoin

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	Those helminth providers who request payment in bitcoins include detailed Bitcoin guides on their websites to help their customers, and they will assist personally with the process, if asked.		Those helminth providers who request payment in bitcoins include detailed Bitcoin guides on their websites to help their customers, and they will assist personally with the process, if asked.

	For those who prefer not to get involved with ~~Bitcoin~~ themselves, there are trustworthy members of the Helminthic Therapy Support group who will exchange PayPal payments or bank wires for ~~bitcoins~~, which they will then send directly to the appropriate provider on behalf of the customer. For ~~further details~~, see the posts at the following links.		For those who prefer not to get involved with bitcoin themselves, there are trustworthy members of the Helminthic Therapy Support group who will exchange PayPal payments or bank wires for bitcoin, which they will then send directly to the appropriate provider on behalf of the customer. For more, see the posts and details at the following links.

	* For [https://www.facebook.com/groups/htsupport/permalink/1479835298739087 PayPal payments] send an email to: rasheemo$gmail.com (change $ to @).		* For [https://www.facebook.com/groups/htsupport/permalink/1479835298739087 PayPal payments] send an email to: rasheemo$gmail.com (change $ to @).
	* For [https://www.facebook.com/groups/htsupport/posts/3309194392469826?comment_id=3309197035802895 PayPal payments or bank wires]		* For [https://www.facebook.com/groups/htsupport/posts/3309194392469826?comment_id=3309197035802895 PayPal payments or bank wires] add your details at the bottom of [http://helminthics.webflow.io/ this contact form] and Alé will reply by email.

	==Routing shipments via a different country==		==Routing shipments via a different country==

Helminthic therapy research

Jlm — Wed, 29 Apr 2026 11:52:33 GMT

2015

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	* 2015 Apr 22 [https://pubmed.ncbi.nlm.nih.gov/26155183/ Necrosis and apoptosis in Trichinella spiralis-mediated tumour reduction]		* 2015 Apr 22 [https://pubmed.ncbi.nlm.nih.gov/26155183/ Necrosis and apoptosis in Trichinella spiralis-mediated tumour reduction]
	* 2015 Apr 19 [https://pubmed.ncbi.nlm.nih.gov/25941654 Type 1 diabetes pathogenesis - Prevention???] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413393/ Full text]		* 2015 Apr 19 [https://pubmed.ncbi.nlm.nih.gov/25941654 Type 1 diabetes pathogenesis - Prevention???] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413393/ Full text]
	* ✅⚡2015 Apr 18 [~~[media~~:~~Overcoming_Evolutionary_Mismatch_by_Self~~-~~Treatment_with_Helminths~~.~~pdf \|~~ Overcoming Evolutionary Mismatch by Self-Treatment with Helminths: Current Practices and Experience]] (PDF) This was the first study to probe the methods and outcomes reported by individuals self-treating with helminths.		* ✅⚡2015 Apr 18 [https://www.ashdin.com/abstract/overcoming-evolutionary-mismatch-by-selftreatment-with-helminths-current-practices-and-experience-3226.html Overcoming Evolutionary Mismatch by Self-Treatment with Helminths: Current Practices and Experience] ([[media:Overcoming_Evolutionary_Mismatch_by_Self-Treatment_with_Helminths.pdf PDF]]) This was the first study to probe the methods and outcomes reported by individuals self-treating with helminths.
	* 2015 Apr 17 [https://pubmed.ncbi.nlm.nih.gov/26040054 Helminths and autoimmunity: the good, the bad and the ugly] -- [https://www.ima.org.il/FilesUpload/IMAJ/0/142/71371.pdf PDF]		* 2015 Apr 17 [https://pubmed.ncbi.nlm.nih.gov/26040054 Helminths and autoimmunity: the good, the bad and the ugly] -- [https://www.ima.org.il/FilesUpload/IMAJ/0/142/71371.pdf PDF]
	* 2015 Apr 15 [https://pubmed.ncbi.nlm.nih.gov/25780044/ Fasciola hepatica fatty acid binding protein inhibits TLR4 activation and suppresses the inflammatory cytokines induced by lipopolysaccharide in vitro and in vivo] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4390499/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4390499/pdf/nihms662872.pdf PDF]		* 2015 Apr 15 [https://pubmed.ncbi.nlm.nih.gov/25780044/ Fasciola hepatica fatty acid binding protein inhibits TLR4 activation and suppresses the inflammatory cytokines induced by lipopolysaccharide in vitro and in vivo] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC4390499/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC4390499/pdf/nihms662872.pdf PDF]

Helminthic therapy and multiple sclerosis (MS)

Jlm — Wed, 29 Apr 2026 10:25:36 GMT

Scientific papers

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	* 2015 Nov [http://www.ncbi.nlm.nih.gov/pubmed/25698173 Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect]		* 2015 Nov [http://www.ncbi.nlm.nih.gov/pubmed/25698173 Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect]
	::This study used a treatment period of only 12 weeks, which is inadequate when assessing the efficacy of helminths, and it also used a novel TSO formulation with a pH of 5, when it is known that storage of TSO above pH4 may impede its therapeutic effect in humans. ~~[https://www.ncbi.nlm.nih.gov/pubmed/28720335]~~ The conclusions drawn by the authors of this study about the efficacy of TSO are therefore not reliable.		::This study used a treatment period of only 12 weeks, which is inadequate when assessing the efficacy of helminths, and it also used a novel TSO formulation with a pH of 5, when it is known that storage of TSO above pH4 may impede its therapeutic effect in humans. The conclusions drawn by the authors of this study about the efficacy of TSO are therefore not reliable.

	* 2015 Jul 25 [http://www.ncbi.nlm.nih.gov/pubmed/26205402 Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis] -- [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513676/ Full text] \| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513676/pdf/40478_2015_Article_223.pdf PDF] (TSO)		* 2015 Jul 25 [http://www.ncbi.nlm.nih.gov/pubmed/26205402 Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis] -- [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513676/ Full text] \| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513676/pdf/40478_2015_Article_223.pdf PDF] (TSO)
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	* 2014 Apr 29 - TSO PH5 - HINT 2 - [http://www.neurology.org/content/82/10_Supplement/P3.149 Clinical Trial of Helminth-induced Immunomodulatory Therapy (HINT 2) in Relapsing-Remitting Multiple Sclerosis (P3.149)] (TSO).		* 2014 Apr 29 - TSO PH5 - HINT 2 - [http://www.neurology.org/content/82/10_Supplement/P3.149 Clinical Trial of Helminth-induced Immunomodulatory Therapy (HINT 2) in Relapsing-Remitting Multiple Sclerosis (P3.149)] (TSO).
	::This trial employed a novel TSO formulation with a pH of 5, when it is known that storage of TSO at a pH above 4 may impede its therapeutic effect in humans. ~~[https://www.ncbi.nlm.nih.gov/pubmed/28720335]~~ The conclusions drawn by the authors of this study about the efficacy of TSO are therefore not reliable.		::This trial employed a novel TSO formulation with a pH of 5, when it is known that storage of TSO at a pH above 4 may impede its therapeutic effect in humans. The conclusions drawn by the authors of this study about the efficacy of TSO are therefore not reliable.
	::('''NB''' the phase 1 (HINT1 with TSO PH 2.3 was successfull: [https://pubmed.ncbi.nlm.nih.gov/21372112/ Probiotic helminth administration in relapsing-remitting multiple sclerosis: a phase 1 study] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894910/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894910/pdf/nihms536054.pdf PDF])		::('''NB''' the phase 1 (HINT1 with TSO PH 2.3 was successfull: [https://pubmed.ncbi.nlm.nih.gov/21372112/ Probiotic helminth administration in relapsing-remitting multiple sclerosis: a phase 1 study] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894910/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894910/pdf/nihms536054.pdf PDF])

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	* 2012 Sept [http://www.ncbi.nlm.nih.gov/pubmed/21838960 Immune monitoring of Trichuris suis egg therapy in multiple sclerosis patients] (TSO in Secondary Progressive Multiple Sclerosis (SPMS))		* 2012 Sept [http://www.ncbi.nlm.nih.gov/pubmed/21838960 Immune monitoring of Trichuris suis egg therapy in multiple sclerosis patients] (TSO in Secondary Progressive Multiple Sclerosis (SPMS))
			::This trial employed a novel TSO formulation with a pH of 5, when it is known that storage of TSO at a pH above 4 may impede its therapeutic effect in humans. The conclusions drawn by the authors of this study about the efficacy of TSO are therefore not reliable.

	* 2012 Aug 24 [http://www.ncbi.nlm.nih.gov/pubmed/22937527 Does helminth activation of toll-like receptors modulate immune response in multiple sclerosis patients?] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426839/ Full text] \| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426839/pdf/fcimb-02-00112.pdf PDF]		* 2012 Aug 24 [http://www.ncbi.nlm.nih.gov/pubmed/22937527 Does helminth activation of toll-like receptors modulate immune response in multiple sclerosis patients?] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426839/ Full text] \| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426839/pdf/fcimb-02-00112.pdf PDF]

Helminthic therapy clinical trials and observational studies

Jlm — Wed, 29 Apr 2026 10:04:25 GMT

Dr. Falk Pharma GmbH / Coronado Biosciences trials

← Older revision		Revision as of 10:04, 29 April 2026
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	* 2008-2011 - TSO pH 2.4 - Phase 1 - [https://clinicaltrials.gov/study/NCT00645749 HINT1] - [https://pubmed.ncbi.nlm.nih.gov/21372112/ Probiotic helminth administration in relapsing-remitting multiple sclerosis: a phase 1 study] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894910/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894910/pdf/nihms536054.pdf PDF]. See BBC coverage: [https://www.bbc.com/future/article/20130422-feeling-ill-swallow-a-parasite Worm therapy: Why parasites may be good for you]		* 2008-2011 - TSO pH 2.4 - Phase 1 - [https://clinicaltrials.gov/study/NCT00645749 HINT1] - [https://pubmed.ncbi.nlm.nih.gov/21372112/ Probiotic helminth administration in relapsing-remitting multiple sclerosis: a phase 1 study] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894910/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894910/pdf/nihms536054.pdf PDF]. See BBC coverage: [https://www.bbc.com/future/article/20130422-feeling-ill-swallow-a-parasite Worm therapy: Why parasites may be good for you]
	::'''Treatment''': Five subjects with newly diagnosed, treatment-naive relapsing-remitting multiple sclerosis (RRMS) were given 2500 TSO orally every 2 weeks for 3 months in a baseline versus treatment control exploratory trial.		::'''Treatment''': Five subjects with newly diagnosed, treatment-naive relapsing-remitting multiple sclerosis (RRMS) were given 2500 TSO orally every 2 weeks for 3 months in a baseline versus treatment control exploratory trial.
	::'''Results''': The mean number of new gadolinium-enhancing magnetic resonance imaging (MRI) lesions (n-Gd+) fell from 6.6 at baseline to 2.0 at the end of TSO administration. ~~See 2012 Sep [https://pubmed.ncbi.nlm.nih.gov/21838960/ Immune monitoring of Trichuris suis egg therapy in multiple sclerosis patients],~~ See also 2013 Dec 19 [https://www.ncbi.nlm.nih.gov/pubmed/24351232 Serum levels of brain-derived neurotrophic factor (BNDF) in multiple sclerosis patients with Trichuris suis ova therapy] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866952/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866952/pdf/parasite-20-55.pdf PDF]		::'''Results''': The mean number of new gadolinium-enhancing magnetic resonance imaging (MRI) lesions (n-Gd+) fell from 6.6 at baseline to 2.0 at the end of TSO administration. See also 2013 Dec 19 [https://www.ncbi.nlm.nih.gov/pubmed/24351232 Serum levels of brain-derived neurotrophic factor (BNDF) in multiple sclerosis patients with Trichuris suis ova therapy] -- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866952/ Full text] \| [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866952/pdf/parasite-20-55.pdf PDF]
	::'''NB''' HINT2 - see below - was done with a version of TSO at pH 5.0, which is known to be less effective than the TSO product at pH 2.4 that is commercially available and was used in Weinstock's early trials.		::'''NB''' HINT2 - see below - was done with a version of TSO at pH 5.0, which is known to be less effective than the TSO product at pH 2.4 that is commercially available and was used in Weinstock's early trials.

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	::'''Treatment''': Oral inoculation (2,500 ova) every 2 weeks for 12 months. Placebo group included. Total study (n = 50)		::'''Treatment''': Oral inoculation (2,500 ova) every 2 weeks for 12 months. Placebo group included. Total study (n = 50)
	::'''Results''': 2021 Jan 29 [https://pubmed.ncbi.nlm.nih.gov/33572978/ The Worm-Specific Immune Response in Multiple Sclerosis Patients Receiving Controlled Trichuris suis Ova Immunotherapy] -- [https://www.mdpi.com/2075-1729/11/2/101/htm Full text]		::'''Results''': 2021 Jan 29 [https://pubmed.ncbi.nlm.nih.gov/33572978/ The Worm-Specific Immune Response in Multiple Sclerosis Patients Receiving Controlled Trichuris suis Ova Immunotherapy] -- [https://www.mdpi.com/2075-1729/11/2/101/htm Full text]

			* 2012 Sep - TSO pH 5 - Phase 1 - Berlin La Charité - [https://pubmed.ncbi.nlm.nih.gov/21838960/ Immune monitoring of Trichuris suis egg therapy in multiple sclerosis patients]

	* 2015 Nov - TSO pH 5 - [https://clinicaltrials.gov/study/NCT01006941 TRIMS A] - Rigshospitalet, Denmark - [http://www.ncbi.nlm.nih.gov/pubmed/25698173 Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect] This study used a treatment period of only 12 weeks, which is inadequate when assessing the efficacy of helminths, and it also used a novel TSO formulation with a pH of 5, when it is known that storage of TSO at a pH above 4 may impede its therapeutic effect in humans. [https://www.ncbi.nlm.nih.gov/pubmed/28720335] The conclusions drawn by the authors of this study about the efficacy of TSO are therefore not reliable.		* 2015 Nov - TSO pH 5 - [https://clinicaltrials.gov/study/NCT01006941 TRIMS A] - Rigshospitalet, Denmark - [http://www.ncbi.nlm.nih.gov/pubmed/25698173 Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect] This study used a treatment period of only 12 weeks, which is inadequate when assessing the efficacy of helminths, and it also used a novel TSO formulation with a pH of 5, when it is known that storage of TSO at a pH above 4 may impede its therapeutic effect in humans. [https://www.ncbi.nlm.nih.gov/pubmed/28720335] The conclusions drawn by the authors of this study about the efficacy of TSO are therefore not reliable.

Helminthic therapy and multiple sclerosis (MS)

Jlm — Wed, 29 Apr 2026 06:55:46 GMT

Scientific papers

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	* 2023 Jan 17 [https://pubmed.ncbi.nlm.nih.gov/36768183/ Role of Microglial Cells in the Pathophysiology of MS: Synergistic or Antagonistic?]		* 2023 Jan 17 [https://pubmed.ncbi.nlm.nih.gov/36768183/ Role of Microglial Cells in the Pathophysiology of MS: Synergistic or Antagonistic?]
	* 2022 May 23 [https://pubmed.ncbi.nlm.nih.gov/35627315/ Gut Microbiota as a Potential Predictive Biomarker in Relapsing-Remitting Multiple Sclerosis]		* 2022 May 23 [https://pubmed.ncbi.nlm.nih.gov/35627315/ Gut Microbiota as a Potential Predictive Biomarker in Relapsing-Remitting Multiple Sclerosis]
			* 2022 Mar 14 [https://pubmed.ncbi.nlm.nih.gov/35336190/ Microbiota, IgA and Multiple Sclerosis]
	* 2022 Mar 11 [https://pubmed.ncbi.nlm.nih.gov/35327624/ Multiple Sclerosis and Microbiome]		* 2022 Mar 11 [https://pubmed.ncbi.nlm.nih.gov/35327624/ Multiple Sclerosis and Microbiome]
	* 2022 Feb [https://pubmed.ncbi.nlm.nih.gov/35094961/ Alterations of host-gut microbiome interactions in multiple sclerosis]		* 2022 Feb [https://pubmed.ncbi.nlm.nih.gov/35094961/ Alterations of host-gut microbiome interactions in multiple sclerosis]

Helminthic Therapy Wiki

John — Wed, 29 Apr 2026 04:25:35 GMT

← Older revision		Revision as of 04:25, 29 April 2026
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	<div style="font-size:18px;">[[Contents \| '''Site contents and navigation''']]</div>		<div style="font-size:18px;">[[Contents \| '''Site contents and navigation''']]</div>
	<hr>		<hr>
	* [https://www.helminthictherapywiki.org/wiki/Special:Chatbot '''Chatbot'''] (Click icon, bottom right)		<!--* [https://www.helminthictherapywiki.org/wiki/Special:Chatbot '''Chatbot'''] (Click icon, bottom right)-->
	* [[Index to topics \| '''Index to topics''']]		* [[Index to topics \| '''Index to topics''']]
	* [[Special:AllPages \|'''List of pages''']]		* [[Special:AllPages \|'''List of pages''']]

The history of helminthic therapy

John — Wed, 29 Apr 2026 03:21:59 GMT

2023

← Older revision		Revision as of 03:21, 29 April 2026
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	=== 2023 ===		=== 2023 ===

	* The Australian helminth provider, [https://www.guthappy.com.au/helminthic-therapy/ Gut Happy Pty Ltd], ceased trading after being contacted by the Australian Government's Therapeutic Goods Administration, who had been alerted by a local journalist ~~to details on their website~~.		* The Australian helminth provider, [https://www.guthappy.com.au/helminthic-therapy/ Gut Happy Pty Ltd], ceased trading after being contacted by the Australian Government's Therapeutic Goods Administration, who had been alerted to details on the company's website by a local journalist.

	== Helminthic therapy today ==		== Helminthic therapy today ==

Human helminth care manual

John — Wed, 29 Apr 2026 03:05:32 GMT

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	'''<font color=#B40431><font size=2>It is thought to be less likely that anything will harm NA before it attaches to the gut mucosa towards the end of the third week post inoculation</font></font>''', although, once NA enters the bloodstream, it does begin to feed on proteins in the blood. [https://www.facebook.com/groups/htsupport/permalink/1682302251825723/?comment_id=1682333608489254&comment_tracking=%7B%22tn%22%3A%22R0%22%7D] [https://www.ncbi.nlm.nih.gov/pubmed/29566094]. After it arrives in the small intestine and begins feeding from the gut wall from day 21, NA will always be vulnerable to anything harmful that has entered its host's blood.		'''<font color=#B40431><font size=2>It is thought to be less likely that anything will harm NA before it attaches to the gut mucosa towards the end of the third week post inoculation</font></font>''', although, once NA enters the bloodstream, it does begin to feed on proteins in the blood. [https://www.facebook.com/groups/htsupport/permalink/1682302251825723/?comment_id=1682333608489254&comment_tracking=%7B%22tn%22%3A%22R0%22%7D] [https://www.ncbi.nlm.nih.gov/pubmed/29566094]. After it arrives in the small intestine and begins feeding from the gut wall from day 21, NA will always be vulnerable to anything harmful that has entered its host's blood.

	'''<font color=#B40431><font size=2>Substances that are applied to the skin topically in small quantities are unlikely to cause harm to human helminths, even if ~~they~~ are known to be a risk when ingested.</font></font>'''		'''<font color=#B40431><font size=2>Substances that are applied to the skin topically in small quantities are unlikely to cause harm to human helminths, even if the substances are known to be a risk when they are ingested.</font></font>'''

	'''<font color=#B40431><font size=2>Due to the way that TT feeds and attaches to the colonic mucosa, it is not as vulnerable as NA</font></font>''', as is illustrated by the fact that three times more of the anthelmintic drug, mebendazole, may be required to kill TT than to kill NA.		'''<font color=#B40431><font size=2>Due to the way that TT feeds and attaches to the colonic mucosa, it is not as vulnerable as NA</font></font>''', as is illustrated by the fact that three times more of the anthelmintic drug, mebendazole, may be required to kill TT than to kill NA.

Helminth providers

John — Wed, 29 Apr 2026 00:10:26 GMT

Help with using Bitcoin

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	For those who prefer not to get involved with Bitcoin themselves, there are trustworthy members of the Helminthic Therapy Support group who will exchange PayPal payments or bank wires for bitcoins, which they will then send directly to the appropriate provider on behalf of the customer. For further details, see the posts at the following links.		For those who prefer not to get involved with Bitcoin themselves, there are trustworthy members of the Helminthic Therapy Support group who will exchange PayPal payments or bank wires for bitcoins, which they will then send directly to the appropriate provider on behalf of the customer. For further details, see the posts at the following links.

	* For [https://www.facebook.com/groups/htsupport/permalink/1479835298739087 PayPal payments]		* For [https://www.facebook.com/groups/htsupport/permalink/1479835298739087 PayPal payments] send an email to: rasheemo$gmail.com (change $ to @).
	* For [https://www.facebook.com/groups/htsupport/posts/3309194392469826?comment_id=3309197035802895 PayPal payments or bank wires]		* For [https://www.facebook.com/groups/htsupport/posts/3309194392469826?comment_id=3309197035802895 PayPal payments or bank wires]

Helminthic therapy and multiple sclerosis (MS)

Jlm — Tue, 28 Apr 2026 20:46:05 GMT

Scientific papers

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	* 2015 Jan [https://pubmed.ncbi.nlm.nih.gov/25282335/ Neutralizing IL-17 protects the optic nerve from autoimmune pathology and prevents retinal nerve fiber layer atrophy during experimental autoimmune encephalomyelitis]		* 2015 Jan [https://pubmed.ncbi.nlm.nih.gov/25282335/ Neutralizing IL-17 protects the optic nerve from autoimmune pathology and prevents retinal nerve fiber layer atrophy during experimental autoimmune encephalomyelitis]
	* 2015 [https://www.tara.tcd.ie/items/7a7a77a0-23ba-4e89-9ecf-88f4631518aa The role of T cell subsets in experimental autoimmune encephalomyelitis]		* 2015 [https://www.tara.tcd.ie/items/7a7a77a0-23ba-4e89-9ecf-88f4631518aa The role of T cell subsets in experimental autoimmune encephalomyelitis]
			* 2014 Aug [https://pubmed.ncbi.nlm.nih.gov/25084177/ Gut commensalism, cytokines, and central nervous system demyelination]
	* 2013 Sep [https://pubmed.ncbi.nlm.nih.gov/23664544/ High interleukin-10 expression within the central nervous system may be important for initiation of recovery of Dark Agouti rats from experimental autoimmune encephalomyelitis]		* 2013 Sep [https://pubmed.ncbi.nlm.nih.gov/23664544/ High interleukin-10 expression within the central nervous system may be important for initiation of recovery of Dark Agouti rats from experimental autoimmune encephalomyelitis]
	* 2011 Mar [https://pubmed.ncbi.nlm.nih.gov/21091909/ Oestrogen-mediated protection of experimental autoimmune encephalomyelitis in the absence of Foxp3+ regulatory T cells implicates compensatory pathways including regulatory B cells] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3044900/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC3044900/pdf/imm0132-0340.pdf PDF]		* 2011 Mar [https://pubmed.ncbi.nlm.nih.gov/21091909/ Oestrogen-mediated protection of experimental autoimmune encephalomyelitis in the absence of Foxp3+ regulatory T cells implicates compensatory pathways including regulatory B cells] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC3044900/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC3044900/pdf/imm0132-0340.pdf PDF]

Mechanisms underlying helminth colonization

Jlm — Tue, 28 Apr 2026 20:44:04 GMT

Studies of Trichuris

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	* 2015 May 21 [http://pubmed.ncbi.nlm.nih.gov/25996526 Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells]		* 2015 May 21 [http://pubmed.ncbi.nlm.nih.gov/25996526 Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells]
	* 2015 Jul 25 [http://pubmed.ncbi.nlm.nih.gov/26205402 Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis]		* 2015 Jul 25 [http://pubmed.ncbi.nlm.nih.gov/26205402 Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis]
			* 2015 Jul 15 [https://pubmed.ncbi.nlm.nih.gov/26174801/ Bacteria-induced egg hatching differs for Trichuris muris and Trichuris suis]
	* 2015 Jul [https://pubmed.ncbi.nlm.nih.gov/26008635/ In vitro hatching of Trichuris suis eggs]		* 2015 Jul [https://pubmed.ncbi.nlm.nih.gov/26008635/ In vitro hatching of Trichuris suis eggs]
	* 2015 Jun [http://eprints.uanl.mx/9708/ Efecto de la administración de huevos de trichuris suis en la reparación del tejido intestinal y producción de citocinas en un modelo murino de colitis] (Master, Nuevo León, Spanish)		* 2015 Jun [http://eprints.uanl.mx/9708/ Efecto de la administración de huevos de trichuris suis en la reparación del tejido intestinal y producción de citocinas en un modelo murino de colitis] (Master, Nuevo León, Spanish)

Helminthic therapy and multiple sclerosis (MS)

Jlm — Tue, 28 Apr 2026 20:43:01 GMT

Scientific papers

Helminthic therapy and food intolerance

John — Tue, 28 Apr 2026 16:17:41 GMT

Total food allergy/ intolerance

Helminthic therapy personal stories

John — Tue, 28 Apr 2026 16:06:18 GMT

SIBO

@@ Line 1,267: / Line 1,267: @@
 === SIBO ===
-Also see [[Helminthic therapy and small intestinal bacterial overgrowth (SIBO) | '''Helminthic therapy and small intestinal bacterial overgrowth (SIBO)''']].
+See [[Helminthic therapy and small intestinal bacterial overgrowth (SIBO) | '''Helminthic therapy and small intestinal bacterial overgrowth (SIBO)''']].
 === Sinusitis ===

Helminthic therapy and small intestinal bacterial overgrowth (SIBO)

John — Tue, 28 Apr 2026 16:05:23 GMT

Also worth noting

← Older revision		Revision as of 16:05, 28 April 2026
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	[https://en.wikipedia.org/wiki/Small_intestinal_bacterial_overgrowth SIBO] can be challenging to treat, and it may be best to do whatever one can to get the SIBO under control before starting helminthic therapy.		[https://en.wikipedia.org/wiki/Small_intestinal_bacterial_overgrowth SIBO] can be challenging to treat, and it may be best to do whatever one can to get the SIBO under control before starting helminthic therapy.

	One individual began by taking the herbal, Atrantil, in combination with appropriate dietary changes and efforts to boost gut motility using vagus nerve stimulation, before adding hookworms for longer term management of SIBO~~. His post also contains a number of useful practical tips~~. [https://www.facebook.com/groups/htsupport/permalink/1145061378883149/?comment_id=1145239628865324&comment_tracking=%7B%22tn%22%3A%22R%22%7D]		One individual began by taking the herbal, Atrantil, in combination with appropriate dietary changes and efforts to boost gut motility using vagus nerve stimulation, before adding hookworms for longer term management of SIBO. [https://www.facebook.com/groups/htsupport/permalink/1145061378883149/?comment_id=1145239628865324&comment_tracking=%7B%22tn%22%3A%22R%22%7D His post] also contains a number of useful practical tips.

	Here is how another helminth self-treater approached this.		Here is how another helminth self-treater approached this.
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	Some doctors have apparently told their patients that helminths don’t work in someone who has SIBO. However, there is no evidence for this claim, and one doctor has been reported to have found that SIBO is easier to manage using conventional therapies when HDC are being taken at the same time. (Link expired.)		Some doctors have apparently told their patients that helminths don’t work in someone who has SIBO. However, there is no evidence for this claim, and one doctor has been reported to have found that SIBO is easier to manage using conventional therapies when HDC are being taken at the same time. (Link expired.)

	The fact that helminthic therapy ~~can~~ help SIBO can be seen from the entries ~~for this condition on~~ the ~~following page~~.		The fact that helminthic therapy is able to help SIBO can be seen from the entries in the anecdotal evidence section, below.

	* [[Helminthic therapy personal stories#SIBO \| '''Helminthic therapy personal stories: SIBO''']]

	While helminthic therapy can improve SIBO in the longer term, the gastrointestinal side effects that are possible following the first introduction of hookworms may exacerbate SIBO before eventually improving it, and there has been one case where each new dose of NA taken by a patient with SIBO caused the condition to flare temporarily.		While helminthic therapy can improve SIBO in the longer term, the gastrointestinal side effects that are possible following the first introduction of hookworms may exacerbate SIBO before eventually improving it, and there has been one case where each new dose of NA taken by a patient with SIBO caused the condition to flare temporarily.
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	If someone were to develop SIBO while hosting helminths, the condition can be treated medically before inoculating with more worms.		If someone were to develop SIBO while hosting helminths, the condition can be treated medically before inoculating with more worms.
	{{Quote\|indent}}I took metronidazole, according to the medical protocol (750mg of metronidazole daily [250mg every 8 hours] for 7 days), and immediately afterwards (re)inoculated myself with NAs. This put an end to SIBO and allowed HT to work in the best possible way. [https://www.facebook.com/groups/htsupport/permalink/2033838740005404/] [https://www.facebook.com/groups/htsupport/permalink/3668355803220348/?comment_id=3669837069738888&reply_comment_id=3670950452960883]{{Quote\|/indent}}		{{Quote\|indent}}I took metronidazole, according to the medical protocol (750mg of metronidazole daily [250mg every 8 hours] for 7 days), and immediately afterwards (re)inoculated myself with NAs. This put an end to SIBO and allowed HT to work in the best possible way. [https://www.facebook.com/groups/htsupport/permalink/2033838740005404/] [https://www.facebook.com/groups/htsupport/permalink/3668355803220348/?comment_id=3669837069738888&reply_comment_id=3670950452960883]{{Quote\|/indent}}

			== The anecdotal evidence ==

			The first two reports are more detailed than the quotes that follow them.
			:* [[Treating SIBO and sinusitis with NA and TTO \| '''Treating SIBO and sinusitis with NA and TTO''']]
			:* [[Treating SIBO and metal allergy with helminthic therapy \| '''Treating SIBO and metal allergy with helminthic therapy''']]

			* “In my case hookworm do seem to help SIBO. I’m sitting here right now hearing healthy movement in my gut. One of the most debilitating symptoms of SIBO for me has been high blood pressure spikes and rapid pulse, plus insomnia. With hookworm on board I’m feeling much better in this regard. If anything, my BP is on the lower side of normal. My face has also cleared up, brain fog is greatly improved, and i have more energy.”

			* “I have already tried antibiotics (including rifaximin and neomycin) to no avail. HT, FMT and dietary changes have been most effective so far for me. NA have greatly improved my quality of life. I can now digest/absorb GOS and fructose without any issues.” [https://www.facebook.com/groups/htsupport/permalink/1509328469123103/?comment_id=1554719764583973&reply_comment_id=1555522701170346&comment_tracking=%7B%22tn%22%3A%22R9%22%7D] [https://www.facebook.com/groups/htsupport/permalink/1509328469123103/?comment_id=1511116095611007&comment_tracking=%7B%22tn%22%3A%22R0%22%7D] [https://www.facebook.com/groups/htsupport/permalink/1001536179902337/?comment_id=1001542496568372&reply_comment_id=1005809582808330&comment_tracking=%7B%22tn%22:%22R4%22%7D]

			* “I’ve just hit the 14th week with 25 hw on board and my IBS(D) / SIBO has improved about 50 percent and it is improving every week!” [https://www.facebook.com/groups/htsupport/permalink/1654846481237967/]

			* “I've been using HDC for several months and largely I can say my SIBO is gone.” [https://www.facebook.com/groups/htsupport/permalink/3582086288513967/?comment_id=3592712530784676]

	== Also worth noting ==		== Also worth noting ==

About

John — Tue, 28 Apr 2026 14:31:13 GMT

Visitor comments

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	{{Quote\|indent}}The wiki is great! So organized, easy to navigate and search. It's really wonderful. Your work has been immense in the spreading of helminth therapy knowledge.{{Quote\|/indent}}		{{Quote\|indent}}The wiki is great! So organized, easy to navigate and search. It's really wonderful. Your work has been immense in the spreading of helminth therapy knowledge.{{Quote\|/indent}}

	{{Quote\|indent}}I am a clinician in the US and I have done lots of searching through the Wiki... Excellent resource ~~btw~~! I realize you are not a clinician, but you have certainly gained a level of experience and expertise that many doctors etc do not have in this realm.{{Quote\|/indent}}		{{Quote\|indent}}I am a clinician in the US and I have done lots of searching through the Wiki... Excellent resource! I realize you are not a clinician, but you have certainly gained a level of experience and expertise that many doctors etc do not have in this realm.{{Quote\|/indent}}

	{{Quote\|indent}}Thank you for this resource you have created. it's an incredible thing that’s helping to change a lot of lives.{{Quote\|/indent}}		{{Quote\|indent}}Thank you for this resource you have created. it's an incredible thing that’s helping to change a lot of lives.{{Quote\|/indent}}

Mechanisms underlying helminth colonization

Jlm — Tue, 28 Apr 2026 06:42:55 GMT

CD4+ Th17 cells

← Older revision		Revision as of 06:42, 28 April 2026
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	=== CD4+ Th17 cells ===		=== CD4+ Th17 cells ===

	* 2026 Apr 13 [https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1767639/abstract Helminth exposure influences Th17 plasticity, suppressing inflammatory and promoting regulatory activity by Th17 lineage cells] ~~(Online ahead of print)~~		* 2026 Apr 28 [https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1767639/abstract Helminth exposure influences Th17 plasticity, suppressing inflammatory and promoting regulatory activity by Th17 lineage cells]
	* 2026 Mar [https://pubmed.ncbi.nlm.nih.gov/41823215/ Comparison Between Phenotypic Profile and Functional Aspects of IL-9-Producing Lymphocytes, Th17 and Tfh of Individuals From Endemic and Non-Endemic Areas for Hookworm Infection]		* 2026 Mar [https://pubmed.ncbi.nlm.nih.gov/41823215/ Comparison Between Phenotypic Profile and Functional Aspects of IL-9-Producing Lymphocytes, Th17 and Tfh of Individuals From Endemic and Non-Endemic Areas for Hookworm Infection]
	* 2026 Jan 16 [https://pubmed.ncbi.nlm.nih.gov/41513004/ Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism]		* 2026 Jan 16 [https://pubmed.ncbi.nlm.nih.gov/41513004/ Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism]

Helminthic therapy research

Jlm — Tue, 28 Apr 2026 06:41:30 GMT

2026

← Older revision		Revision as of 06:41, 28 April 2026
Line 127:		Line 127:

	* 2026 Apr 30 [https://pubmed.ncbi.nlm.nih.gov/41984489/ Helminth Excretory/Secretory Proteins Ameliorate Colitis Through Preservation of Intestinal Homeostasis]		* 2026 Apr 30 [https://pubmed.ncbi.nlm.nih.gov/41984489/ Helminth Excretory/Secretory Proteins Ameliorate Colitis Through Preservation of Intestinal Homeostasis]
			* 2026 Apr 28 [https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1767639/abstract Helminth exposure influences Th17 plasticity, suppressing inflammatory and promoting regulatory activity by Th17 lineage cells]
	* 2026 Apr 15 [https://pubmed.ncbi.nlm.nih.gov/41915399/ Molecular engineering of the helminth TGF-β mimetics, TGM1 and TGM4 reveals a novel antagonist of TGF-β signaling in fibroblasts]		* 2026 Apr 15 [https://pubmed.ncbi.nlm.nih.gov/41915399/ Molecular engineering of the helminth TGF-β mimetics, TGM1 and TGM4 reveals a novel antagonist of TGF-β signaling in fibroblasts]
	* 2026 Apr 13 [https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1767639/abstract Helminth exposure influences Th17 plasticity, suppressing inflammatory and promoting regulatory activity by Th17 lineage cells] (Online ahead of print)
	* 2026 Apr 1 [https://pubmed.ncbi.nlm.nih.gov/41935913/ The evolutionary origins of multiple sclerosis] -- [https://www.sciencedirect.com/science/article/abs/pii/S0035378726004960 Full text] (Online ahead of print)		* 2026 Apr 1 [https://pubmed.ncbi.nlm.nih.gov/41935913/ The evolutionary origins of multiple sclerosis] -- [https://www.sciencedirect.com/science/article/abs/pii/S0035378726004960 Full text] (Online ahead of print)
	* 2026 Mar 31 [https://pubmed.ncbi.nlm.nih.gov/41918093/ Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria]		* 2026 Mar 31 [https://pubmed.ncbi.nlm.nih.gov/41918093/ Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria]

Helminthic therapy and neurodegenerative diseases

Jlm — Tue, 28 Apr 2026 06:34:57 GMT

Microbiota-gut-brain axis dysregulation

← Older revision		Revision as of 06:34, 28 April 2026
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	* 2024 Oct 8 [https://pubmed.ncbi.nlm.nih.gov/39379597/ Examining the complex Interplay between gut microbiota abundance and short-chain fatty acid production in amyotrophic lateral sclerosis patients shortly after onset of disease]		* 2024 Oct 8 [https://pubmed.ncbi.nlm.nih.gov/39379597/ Examining the complex Interplay between gut microbiota abundance and short-chain fatty acid production in amyotrophic lateral sclerosis patients shortly after onset of disease]
	* 2024 Oct [https://pubmed.ncbi.nlm.nih.gov/39460538/ The Gut Microbiota Modulates Neuroinflammation in Alzheimer's Disease: Elucidating Crucial Factors and Mechanistic Underpinnings] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11512114/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC11512114/pdf/CNS-30-e70091.pdf PDF]		* 2024 Oct [https://pubmed.ncbi.nlm.nih.gov/39460538/ The Gut Microbiota Modulates Neuroinflammation in Alzheimer's Disease: Elucidating Crucial Factors and Mechanistic Underpinnings] -- [https://pmc.ncbi.nlm.nih.gov/articles/PMC11512114/ Full text] \| [https://pmc.ncbi.nlm.nih.gov/articles/PMC11512114/pdf/CNS-30-e70091.pdf PDF]
			* 2024 Oct [https://pubmed.ncbi.nlm.nih.gov/39482179/ Thinking outside the brain: Gut microbiome influence on innate immunity within neurodegenerative disease]
	* 2024 Sep [https://pubmed.ncbi.nlm.nih.gov/37787835/ The gut microbiome: an important role in neurodegenerative diseases and their therapeutic advances]		* 2024 Sep [https://pubmed.ncbi.nlm.nih.gov/37787835/ The gut microbiome: an important role in neurodegenerative diseases and their therapeutic advances]
	* 2024 Jul 10 [https://dumas.ccsd.cnrs.fr/MEM-UNIV-BORDEAUX/dumas-04642929v1 Le microbiote intestinal, la clé de notre santé mentale ? Implication de l'axe intestin-cerveau dans la physiopathologie de la dépression et de la maladie de Parkinson] -- [https://dumas.ccsd.cnrs.fr/dumas-04642929v1/file/Pharmacie_2024_Quimeby.pdf PDF] (French, pharma thesis)		* 2024 Jul 10 [https://dumas.ccsd.cnrs.fr/MEM-UNIV-BORDEAUX/dumas-04642929v1 Le microbiote intestinal, la clé de notre santé mentale ? Implication de l'axe intestin-cerveau dans la physiopathologie de la dépression et de la maladie de Parkinson] -- [https://dumas.ccsd.cnrs.fr/dumas-04642929v1/file/Pharmacie_2024_Quimeby.pdf PDF] (French, pharma thesis)

Mechanisms underlying helminth colonization

Jlm — Tue, 28 Apr 2026 06:32:29 GMT

Studies of Trichuris

← Older revision		Revision as of 06:32, 28 April 2026
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	* 2016 Jan [https://pubmed.ncbi.nlm.nih.gov/26609699/ Comparison of innate and Th1-type host immune responses in Oesophagostomum dentatum and Trichuris suis infections in pigs]		* 2016 Jan [https://pubmed.ncbi.nlm.nih.gov/26609699/ Comparison of innate and Th1-type host immune responses in Oesophagostomum dentatum and Trichuris suis infections in pigs]
	* 2015 May 21 [http://pubmed.ncbi.nlm.nih.gov/25996526 Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells]		* 2015 May 21 [http://pubmed.ncbi.nlm.nih.gov/25996526 Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells]
	* 2015 Jul 25 [http://pubmed.ncbi.nlm.nih.gov/26205402 Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis] -- [~~http~~://~~www~~.ncbi.nlm.nih.gov/~~pmc~~/~~articles/PMC4513676/ Full text] \| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513676/pdf/40478_2015_Article_223.pdf PDF~~]		* 2015 Jul 25 [http://pubmed.ncbi.nlm.nih.gov/26205402 Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis]
			* 2015 Jul [https://pubmed.ncbi.nlm.nih.gov/26008635/ In vitro hatching of Trichuris suis eggs]
	* 2015 Jun [http://eprints.uanl.mx/9708/ Efecto de la administración de huevos de trichuris suis en la reparación del tejido intestinal y producción de citocinas en un modelo murino de colitis] (Master, Nuevo León, Spanish)		* 2015 Jun [http://eprints.uanl.mx/9708/ Efecto de la administración de huevos de trichuris suis en la reparación del tejido intestinal y producción de citocinas en un modelo murino de colitis] (Master, Nuevo León, Spanish)
	* 2015 Jun [https://pubmed.ncbi.nlm.nih.gov/25716348/ Oral administration of dextran sodium sulphate induces a caecum-localized colitis in rabbits]		* 2015 Jun [https://pubmed.ncbi.nlm.nih.gov/25716348/ Oral administration of dextran sodium sulphate induces a caecum-localized colitis in rabbits]

Helminthic therapy and inflammatory bowel disease (IBD)

Jlm — Tue, 28 Apr 2026 06:29:26 GMT

More scientific studies

← Older revision		Revision as of 06:29, 28 April 2026
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	* 2022 Nov 20 [https://pubmed.ncbi.nlm.nih.gov/36443262/ Schistosoma japonicum Eggs Exerts Protective Effects in an Experimental Ulcerative Colitis Model] -- [https://www.besjournal.com/en/article/doi/10.3967/bes2022.138 Full text]		* 2022 Nov 20 [https://pubmed.ncbi.nlm.nih.gov/36443262/ Schistosoma japonicum Eggs Exerts Protective Effects in an Experimental Ulcerative Colitis Model] -- [https://www.besjournal.com/en/article/doi/10.3967/bes2022.138 Full text]

			* 2022 Oct 31 [https://pubmed.ncbi.nlm.nih.gov/37123156/ Reduce the Changes in Histological Features of Colon Resulting from Induced Ulcerative Colitis in Mice by Worm Antigens]

	* 2022 Oct 27 [https://pubmed.ncbi.nlm.nih.gov/36289514/ Echinococcus granulosus sensu stricto and antigen B may decrease inflammatory bowel disease through regulation of M1/2 polarization] -- [https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-022-05498-y Full text]		* 2022 Oct 27 [https://pubmed.ncbi.nlm.nih.gov/36289514/ Echinococcus granulosus sensu stricto and antigen B may decrease inflammatory bowel disease through regulation of M1/2 polarization] -- [https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-022-05498-y Full text]

Helminthic therapy research

Jlm — Tue, 28 Apr 2026 06:27:54 GMT

2022

← Older revision		Revision as of 06:27, 28 April 2026
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	* 2022 Nov [https://www.researchgate.net/profile/Anas-E-Almousawi/publication/365401339_Did_helminths_guard_against_autoimmune_conditions/links/6373bbfd54eb5f547cd5ab93/Did-helminths-guard-against-autoimmune-conditions.pdf Did helminths guard against autoimmune conditions?]		* 2022 Nov [https://www.researchgate.net/profile/Anas-E-Almousawi/publication/365401339_Did_helminths_guard_against_autoimmune_conditions/links/6373bbfd54eb5f547cd5ab93/Did-helminths-guard-against-autoimmune-conditions.pdf Did helminths guard against autoimmune conditions?]

			* 2022 Oct 31 [https://pubmed.ncbi.nlm.nih.gov/37123156/ Reduce the Changes in Histological Features of Colon Resulting from Induced Ulcerative Colitis in Mice by Worm Antigens]

	* 2022 Oct 27 [https://pubmed.ncbi.nlm.nih.gov/36289514/ Echinococcus granulosus sensu stricto and antigen B may decrease inflammatory bowel disease through regulation of M1/2 polarization] -- [https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-022-05498-y Full text]		* 2022 Oct 27 [https://pubmed.ncbi.nlm.nih.gov/36289514/ Echinococcus granulosus sensu stricto and antigen B may decrease inflammatory bowel disease through regulation of M1/2 polarization] -- [https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-022-05498-y Full text]

Helminthic therapy and food intolerance

John — Tue, 28 Apr 2026 00:39:57 GMT

Alcohol intolerance

← Older revision		Revision as of 00:39, 28 April 2026
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	* “I can tolerate beer better with HW” [https://www.facebook.com/groups/htsupport/permalink/848418981880725/?comment_id=848501681872455]<!-- BK -->		* “I can tolerate beer better with HW” [https://www.facebook.com/groups/htsupport/permalink/848418981880725/?comment_id=848501681872455]<!-- BK -->

	* “I shared a bottle of wine with my husband (after 4 doses of 2500 TSO) for the first time in 8 years. I did not feel like death the next day. Amazing!” [https://www.facebook.com/groups/htsupport/permalink/3695008493888412?comment_id=3809529635769630]<!-- RO'N -->== Media coverage ==		* “I shared a bottle of wine with my husband (after 4 doses of 2500 TSO) for the first time in 8 years. I did not feel like death the next day. Amazing!” [https://www.facebook.com/groups/htsupport/permalink/3695008493888412?comment_id=3809529635769630]<!-- RO'N -->

			== Media coverage ==

	* 2015 Nov 10 [http://www.abc.net.au/news/2015-11-10/hookworm-larvae-injected-into-coeliacs-gluten-intolerance/6926286 Hookworm larvae to be injected into coeliacs in bid to treat gluten intolerance] - ABC News		* 2015 Nov 10 [http://www.abc.net.au/news/2015-11-10/hookworm-larvae-injected-into-coeliacs-gluten-intolerance/6926286 Hookworm larvae to be injected into coeliacs in bid to treat gluten intolerance] - ABC News

Helminthic therapy personal stories

John — Tue, 28 Apr 2026 00:33:23 GMT

Alcohol intolerance

← Older revision		Revision as of 00:33, 28 April 2026
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	=== Alcohol intolerance ===		=== Alcohol intolerance ===

	* “... after hosting HWs for 9 months I too can also drink alcohol which I could not do previously. Beer is good again.” [~~https://www.facebook.com/groups/htsupport/permalink/848418981880725/?comment_id=848726048516685&comment_tracking=%7B%22tn%22:%22R9%22%7D]~~		See [[Helminthic therapy and food intolerance \| '''Helminthic therapy and food intolerance: Alcohol intolerance''']]

	* “I can now drink alcohol without becoming intoxicated after 3 sips of wine. It was lovely to be able to drink a full glass of wine.” [~~https~~:~~//www.facebook.com/groups/htsupport/permalink/2255349147854361?comment_id=3497089627013634~~]~~<!-- Christina Thomas -->~~

	* “I find that I am MUCH less likely to be hungover after drinking the night before while hosting worms.” [https://www.facebook.com/groups/htsupport/permalink/1276571042398848/?comment_id=1604202039635745&comment_tracking=%7B%22tn%22%3A%22R%22%7D]~~<!-- AS -->~~

	* “I can tolerate beer better with HW” [https://www.facebook.com/groups/htsupport/permalink/848418981880725/?comment_id=848501681872455]<!-- BK -->

	* “I shared a bottle of wine with my husband (after 4 doses of 2500 TSO) for the first time in 8 years. I did not feel like death the next day. Amazing!” [https://www.facebook.com/groups/htsupport/permalink/3695008493888412?comment_id=3809529635769630]<!-- RO'N -->

	=== Allergy ===		=== Allergy ===

Helminthic therapy and food intolerance

John — Tue, 28 Apr 2026 00:31:15 GMT

Media coverage

← Older revision		Revision as of 00:31, 28 April 2026
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	* "This is my 1 year update of using helminthic therapy for severe Crohn’s disease and total food intolerance. Right now I am ecstatic! As of this week my doctor has told me my labs show that I am in clinical remission!! My calprotectin is at a 15, and my CRP is within the normal range. In the past my Calprotectin has been so high that it was beyond the range they test for… I am still in disbelief. This is the first time I have been in remission in over 3 years. I am still currently experiencing 50% loose stools and nocturnal bowel movements… but that’s it! Symptoms that have been healed are: weekly vomiting, weekly blood in stools, constant nausea, pain, discomfort and unease, urgency, fatigue, and all issues with eating (like having to run to the toilet immediately after putting something in my mouth) and total complete food intolerance. For 3 years I got most of my calories from meal replacement shakes but, in the past year, my total food intolerance has been reduced by about 80%. So overall amazing progress!!… I feel positive and am looking forward to my future for the first time in a long time. For the first time in over 12 months I am fully off of the steroid prednisolone!!! After trying and failing so many times to get off the drug because IBD symptoms would come back so full on, I’ve now successfully gotten off of it! I have found the natural medicine I have been searching for all these years. 13 years of suffering and all I had to do was take some bloody worms…" (Edited from [https://letshealibd.com/2024/07/24/one-year-update-of-using-helminthic-therapy/ this blog post].)<!--KM-->		* "This is my 1 year update of using helminthic therapy for severe Crohn’s disease and total food intolerance. Right now I am ecstatic! As of this week my doctor has told me my labs show that I am in clinical remission!! My calprotectin is at a 15, and my CRP is within the normal range. In the past my Calprotectin has been so high that it was beyond the range they test for… I am still in disbelief. This is the first time I have been in remission in over 3 years. I am still currently experiencing 50% loose stools and nocturnal bowel movements… but that’s it! Symptoms that have been healed are: weekly vomiting, weekly blood in stools, constant nausea, pain, discomfort and unease, urgency, fatigue, and all issues with eating (like having to run to the toilet immediately after putting something in my mouth) and total complete food intolerance. For 3 years I got most of my calories from meal replacement shakes but, in the past year, my total food intolerance has been reduced by about 80%. So overall amazing progress!!… I feel positive and am looking forward to my future for the first time in a long time. For the first time in over 12 months I am fully off of the steroid prednisolone!!! After trying and failing so many times to get off the drug because IBD symptoms would come back so full on, I’ve now successfully gotten off of it! I have found the natural medicine I have been searching for all these years. 13 years of suffering and all I had to do was take some bloody worms…" (Edited from [https://letshealibd.com/2024/07/24/one-year-update-of-using-helminthic-therapy/ this blog post].)<!--KM-->

	== Media coverage ==		== Alcohol intolerance ==

			* “... after hosting HWs for 9 months I too can also drink alcohol which I could not do previously. Beer is good again.” [https://www.facebook.com/groups/htsupport/permalink/848418981880725/?comment_id=848726048516685&comment_tracking=%7B%22tn%22:%22R9%22%7D]

			* “I can now drink alcohol without becoming intoxicated after 3 sips of wine. It was lovely to be able to drink a full glass of wine.” [https://www.facebook.com/groups/htsupport/permalink/2255349147854361?comment_id=3497089627013634]<!-- Christina Thomas -->

			* “I find that I am MUCH less likely to be hungover after drinking the night before while hosting worms.” [https://www.facebook.com/groups/htsupport/permalink/1276571042398848/?comment_id=1604202039635745&comment_tracking=%7B%22tn%22%3A%22R%22%7D]<!-- AS -->

			* “I can tolerate beer better with HW” [https://www.facebook.com/groups/htsupport/permalink/848418981880725/?comment_id=848501681872455]<!-- BK -->

			* “I shared a bottle of wine with my husband (after 4 doses of 2500 TSO) for the first time in 8 years. I did not feel like death the next day. Amazing!” [https://www.facebook.com/groups/htsupport/permalink/3695008493888412?comment_id=3809529635769630]<!-- RO'N -->== Media coverage ==

	* 2015 Nov 10 [http://www.abc.net.au/news/2015-11-10/hookworm-larvae-injected-into-coeliacs-gluten-intolerance/6926286 Hookworm larvae to be injected into coeliacs in bid to treat gluten intolerance] - ABC News		* 2015 Nov 10 [http://www.abc.net.au/news/2015-11-10/hookworm-larvae-injected-into-coeliacs-gluten-intolerance/6926286 Hookworm larvae to be injected into coeliacs in bid to treat gluten intolerance] - ABC News

← Older revision		Revision as of 14:31, 28 April 2026
Line 35:		Line 35:
	{{Quote\|indent}}The wiki is great! So organized, easy to navigate and search. It's really wonderful. Your work has been immense in the spreading of helminth therapy knowledge.{{Quote\|/indent}}		{{Quote\|indent}}The wiki is great! So organized, easy to navigate and search. It's really wonderful. Your work has been immense in the spreading of helminth therapy knowledge.{{Quote\|/indent}}

	{{Quote\|indent}}I am a clinician in the US and I have done lots of searching through the Wiki... Excellent resource ~~btw~~! I realize you are not a clinician, but you have certainly gained a level of experience and expertise that many doctors etc do not have in this realm.{{Quote\|/indent}}		{{Quote\|indent}}I am a clinician in the US and I have done lots of searching through the Wiki... Excellent resource! I realize you are not a clinician, but you have certainly gained a level of experience and expertise that many doctors etc do not have in this realm.{{Quote\|/indent}}

	{{Quote\|indent}}Thank you for this resource you have created. it's an incredible thing that’s helping to change a lot of lives.{{Quote\|/indent}}		{{Quote\|indent}}Thank you for this resource you have created. it's an incredible thing that’s helping to change a lot of lives.{{Quote\|/indent}}

← Older revision		Revision as of 20:43, 28 April 2026
(2 intermediate revisions by the same user not shown)
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	* 2024 May [https://pubmed.ncbi.nlm.nih.gov/38880650/ Microglia and Dendritic Cells as a Source of IL-6 in a Mouse Model of Multiple Sclerosis]		* 2024 May [https://pubmed.ncbi.nlm.nih.gov/38880650/ Microglia and Dendritic Cells as a Source of IL-6 in a Mouse Model of Multiple Sclerosis]
	* 2023 Aug 3 [https://pubmed.ncbi.nlm.nih.gov/37600781/ Under the influence: environmental factors as modulators of neuroinflammation through the IL-10/IL-10R axis]		* 2023 Aug 3 [https://pubmed.ncbi.nlm.nih.gov/37600781/ Under the influence: environmental factors as modulators of neuroinflammation through the IL-10/IL-10R axis]
			* 2023 Jul 31 [https://pubmed.ncbi.nlm.nih.gov/37663721/ Remyelination in multiple sclerosis, along with its immunology and association with gut dysbiosis, lifestyle, and environmental factors]
	* 2023 Apr [https://pubmed.ncbi.nlm.nih.gov/36300567/ Cell therapy procedure using anti-inflammatory macrophage M2 can potentially reduce Clinical Score in animals with Experimental Autoimmune Encephalomyelitis: A preclinical systematic review and meta-analysis study]		* 2023 Apr [https://pubmed.ncbi.nlm.nih.gov/36300567/ Cell therapy procedure using anti-inflammatory macrophage M2 can potentially reduce Clinical Score in animals with Experimental Autoimmune Encephalomyelitis: A preclinical systematic review and meta-analysis study]
	* 2023 Jan 17 [https://pubmed.ncbi.nlm.nih.gov/36768183/ Role of Microglial Cells in the Pathophysiology of MS: Synergistic or Antagonistic?]		* 2023 Jan 17 [https://pubmed.ncbi.nlm.nih.gov/36768183/ Role of Microglial Cells in the Pathophysiology of MS: Synergistic or Antagonistic?]
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	* 2022 Jan-Dec [https://pubmed.ncbi.nlm.nih.gov/36184742/ Myeloid-derived suppressor cells prevent disruption of the gut barrier, preserve microbiota composition, and potentiate immunoregulatory pathways in a rat model of experimental autoimmune encephalomyelitis]		* 2022 Jan-Dec [https://pubmed.ncbi.nlm.nih.gov/36184742/ Myeloid-derived suppressor cells prevent disruption of the gut barrier, preserve microbiota composition, and potentiate immunoregulatory pathways in a rat model of experimental autoimmune encephalomyelitis]
	* 2022 Sep [https://pubmed.ncbi.nlm.nih.gov/35931825/ The role of the gut microbiota in multiple sclerosis]		* 2022 Sep [https://pubmed.ncbi.nlm.nih.gov/35931825/ The role of the gut microbiota in multiple sclerosis]
			* 2022 Aug [https://pubmed.ncbi.nlm.nih.gov/35668103/ Thinking outside the box: non-canonical targets in multiple sclerosis]
	* 2021 Dec 3 [https://pubmed.ncbi.nlm.nih.gov/34926318/ Curcumin β-D-Glucuronide Modulates an Autoimmune Model of Multiple Sclerosis with Altered Gut Microbiota in the Ileum and Feces]		* 2021 Dec 3 [https://pubmed.ncbi.nlm.nih.gov/34926318/ Curcumin β-D-Glucuronide Modulates an Autoimmune Model of Multiple Sclerosis with Altered Gut Microbiota in the Ileum and Feces]
	* 2021 Nov 29 [https://open.fau.de/items/3f1ac799-11f9-4729-bea9-a538cf5f89dc Die Wirkung von Propionat auf die Laurat-vermittelte Exazerbation der Neuroinflammation] (Thesis, Erlangen-Nürnberg, German)		* 2021 Nov 29 [https://open.fau.de/items/3f1ac799-11f9-4729-bea9-a538cf5f89dc Die Wirkung von Propionat auf die Laurat-vermittelte Exazerbation der Neuroinflammation] (Thesis, Erlangen-Nürnberg, German)
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	* 2019 Dec 30 [https://pubmed.ncbi.nlm.nih.gov/31888483/ Primary progressive multiple sclerosis in a Russian cohort: relationship with gut bacterial diversity]		* 2019 Dec 30 [https://pubmed.ncbi.nlm.nih.gov/31888483/ Primary progressive multiple sclerosis in a Russian cohort: relationship with gut bacterial diversity]
	* 2017 Jan [https://pubmed.ncbi.nlm.nih.gov/27189037/ Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy]		* 2017 Jan [https://pubmed.ncbi.nlm.nih.gov/27189037/ Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy]
			* 2016 Dec [https://pubmed.ncbi.nlm.nih.gov/27491297/ Environmental factors in autoimmune diseases and their role in multiple sclerosis]
	* 2016 Aug [https://pubmed.ncbi.nlm.nih.gov/27176462/ Gut microbiota in early pediatric multiple sclerosis: a case-control study]		* 2016 Aug [https://pubmed.ncbi.nlm.nih.gov/27176462/ Gut microbiota in early pediatric multiple sclerosis: a case-control study]
	* 2015 Sep 14 [https://pubmed.ncbi.nlm.nih.gov/26367776/ Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters]		* 2015 Sep 14 [https://pubmed.ncbi.nlm.nih.gov/26367776/ Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters]

← Older revision		Revision as of 16:17, 28 April 2026
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	adverse reaction.		adverse reaction.

	The effects of (TFAI) are devastating and frightening to those affected by it and medical support is minimal but, as more cases come to light, a clearer picture of the condition is emerging.		The effects of TFAI are devastating and frightening to those affected by it and medical support is minimal but, as more cases come to light, a clearer picture of the condition is emerging.

	(TFAI) appears to develop in those whose health is already compromised by some other illness, such as M.E./Chronic Fatigue Syndrome, MS, or multiple chemical sensitivity (MCS), or as a direct result of an eosinophilic gastrointestinal disorder (EGID), in which eosinophils - a type of white blood cell - proliferate within the gut.		TFAI appears to develop in those whose health is already compromised by some other illness, such as M.E./Chronic Fatigue Syndrome, MS, or multiple chemical sensitivity (MCS), or as a direct result of an eosinophilic gastrointestinal disorder (EGID), in which eosinophils - a type of white blood cell - proliferate within the gut.

	The reactions experienced by those with (TFAI) are ~~possibly~~ mostly due to intolerance - i.e. caused by some as yet unidentified mechanism - but some reactions may also be due to a true IgE-mediated allergy.		The reactions experienced by those with TFAI are likely to be mostly due to intolerance - i.e., caused by some as yet unidentified mechanism - but some reactions may also be due to a true IgE-mediated allergy.

	The absence of a positive skin prick test result to a food challenge does not necessarily rule out the possibility of true allergy, because it is possible for allergic reactions to take place in the gut without producing positive skin prick test results, but these reactions can only be revealed by carrying out a [https://pmc.ncbi.nlm.nih.gov/articles/PMC1027199/ Colonoscopic allergen provocation (COLAP) test]. As COLAP tests do not appear to be widely used much, if at all, in the UK, nor food intolerance currently verifiable by any means, and since most doctors will only accept the existence of a condition that they can validate via clinical tests, recognition and acceptance of (TFAI) is problematic.		The absence of a positive skin prick test result to a food challenge does not necessarily rule out the possibility of true allergy, because it is possible for allergic reactions to take place in the gut without producing positive skin prick test results, but these reactions can only be revealed by carrying out a [https://pmc.ncbi.nlm.nih.gov/articles/PMC1027199/ Colonoscopic allergen provocation (COLAP) test]. As COLAP tests do not appear to be widely used much, if at all, in the UK, nor food intolerance currently verifiable by any means, and since most doctors will only accept the existence of a condition that they can validate via clinical tests, recognition and acceptance of TFAI is problematic.

	The typical response of doctors, most of whom will rarely, if ever, see a case of (TFAI), is to attribute any symptoms not verified by clinical tests to psychological causes - either in the patients themselves, in the case of adults, or perhaps in a parent when the patient is a child [https://en.wikipedia.org/wiki/Factitious_disorder_imposed_on_another (Factitious disorder imposed on another (FDIA)], previously known as Munchausen syndrome by proxy (MSbP)). However, when patients have had a psychological evaluation, this has invariably found no psychological problem.		The typical response of doctors, most of whom will rarely, if ever, see a case of TFAI, is to attribute any symptoms not verified by clinical tests to psychological causes - either in the patients themselves, in the case of adults, or perhaps in a parent when the patient is a child [https://en.wikipedia.org/wiki/Factitious_disorder_imposed_on_another (Factitious disorder imposed on another (FDIA)], previously known as Munchausen syndrome by proxy (MSbP)). However, when patients have had a psychological evaluation, this has invariably found no psychological problem.

	The onset of (TFAI) can be rapid, but a creeping progression of symptoms over time appears to be more common. The exact nature of symptoms can vary with different foods and between different people. As ever more foods begin to cause reactions, finding anything to eat that does not cause an adverse effect becomes progressively more difficult and may eventually become impossible.		The onset of TFAI can be rapid, but a creeping progression of symptoms over time appears to be more common. The exact nature of symptoms can vary with different foods and between different people. As ever more foods begin to cause reactions, finding anything to eat that does not cause an adverse effect becomes progressively more difficult and may eventually become impossible.

	Although there is no known cure for (TFAI) at the present time, medicine does have the means to manage this disorder, and thereby to keep people alive, by using special medical feeds and other alternative methods of feeding which were developed to manage a variety of conditions. However, expertise in using these approaches to treat (TFAI) is virtually non-existent.		Although there is no known cure for TFAI at the present time, medicine does have the means to manage this disorder, and thereby to keep people alive, by using special medical feeds and other alternative methods of feeding which were developed to manage a variety of conditions. However, expertise in using these approaches to treat TFAI is virtually non-existent.

	Semi-elemental feeds have proved to be the best tolerated form of food - better even than fully elemental feeds such		Semi-elemental feeds have proved to be the best tolerated form of food - better even than fully elemental feeds such
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	In 2009, it emerged that helminthic therapy can provide effective, long-term remission from the symptoms of total food allergy/ intolerance in some individuals. Since then, several patients with this disorder have found relief by hosting safe, probiotic helminths, and lives have been saved as a result.		In 2009, it emerged that helminthic therapy can provide effective, long-term remission from the symptoms of total food allergy/ intolerance in some individuals. Since then, several patients with this disorder have found relief by hosting safe, probiotic helminths, and lives have been saved as a result.

	If helminthic therapy is used by anyone with (TFAI), it needs to be introduced very gradually, and the reintroduction of normal food after successful treatment should also be gradual and very carefully managed.		If helminthic therapy is used by anyone with TFAI, it needs to be introduced very gradually, and the reintroduction of normal food after successful treatment should also be gradual and very carefully managed.

	=== Total food allergy/ intolerance: the anecdotal evidence ===		=== Total food allergy/ intolerance: the anecdotal evidence ===